                         SEQUENCE LISTING

<110>  Crucell Holland B.V.
 
<120>  Cold-Adapted-Viral-Attenuation (CAVA) and Novel Attenuated 
       Poliovirus Strains

<130>  0235 WO 00 ORD

<150>  US 62/013,379
<151>  2014-06-17

<150>  EP14176071.0
<151>  2014-07-08

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  7444
<212>  RNA
<213>  Poliovirus

<400>  1
uuaaaacagc ucugggguug uucccacccc agaggcccac guggcggcca guacaccggu       60

accacgguac ccuuguacgc cuguuuuaua cuccccuccc cguaaacuag aagcacgaaa      120

cacaaguuca auagaagggg guacagacca guaccaccac gaacaagcac uucuguuccc      180

ccggugaggu cacauagacu guccccacgg ucaaaaguga cugauccguu auccgcucac      240

guacuucgga aagccuagua ccaccuugga aucuacgaug cguugcgcuc agcacucgac      300

cccggagugu agcuuaggcu gaugagucug gacguucccc acuggugaca gugguccagg      360

cugcguuggc ggccuaccug ugguccaaaa ccacaggacg cuaguaguga acaaggugug      420

aagagcccac ugagcuaccu gagaauccuc cggccccuga augcggcuaa ucccaaccac      480

ggagcaggua aucgcaaacc agcggucagc cugucguaac gcguaagucu guggcggaac      540

cgacuacuuu ggguguccgu guuuccuuuu auuuuuaugg uggcugcuua uggugacaau      600

cauagauugu uaucauaaag caaauuggau uggccauccg gagugagcua aacuaucuau      660

uucucugagu guuggauucg uuucacccac auucugaaca aucagccuca uuaguguuac      720

ccuguuaaua agacgauauc aucacgaugg gugcucaggu uucaucacag aaagugggcg      780

cacacgaaaa cucaaauaga gcauauggug guucuaccau caauuacacc accauuaauu      840

auuauagaga uucagcuagc aaugcggcuu cgaaacagga cuucucucaa gauccaucca      900

aguucaccga gcccgucaag gacgucuuga uaaagacagc cccaaugcua aacucgccaa      960

acauagaggc uugcggguau agcgauagag uccugcaauu aacacuggga aacuccacua     1020

uaaccacaca ggaagcggcu aauucaauag ucgcuuaugg gcguuggccu gaguaccuga     1080

gagacagcga agccaaucca guggaucaac cgacagaacc agacgucgcu gcauguaggu     1140

uuuauacacu agacaccgug ucuuggacga aagagucgcg aggguggugg uggaaguugc     1200

cugaugcacu gagggacaug ggacuguuug ggcaaaauuu guacuaccac uaccuaggua     1260

gguccgggua cacuguacau guacagugua acgccuccaa auuccaccag ggagcgcuug     1320

ggguauucgc cguaccagag augugcuugg ccggggacag uaacaccacu accacacaca     1380

ccagcuauca aaaugccaau ccuggcgaga aaggaggcac uuucacaggu acguucaccc     1440

cugacaacaa ccagacaucg ccugcccgca gguuuugccc gguggauuac cuuuuuggaa     1500

acggcacauu guuggggaac gccuuugugu ucccgcacca gauaauaaac uuacggacca     1560

auaacugugc cacauuggug cucccuuacg ugaacucccu cucgauagau aguaugguga     1620

agcacaauaa uuggggaauc gcaauaguac cauuggcccc auuaaauuuu gcuaaugagu     1680

ccuccccaga aauuccaauc accuuaacca uagccccuau gugcugugag uucaauggau     1740

uaagaaacau uacccugcca cguuuacagg gccugccggu caugaacacc ccugguagua     1800

aucaauaucu uacugcagac aacuuccagu caccgugugc gcugccugaa uuugacguaa     1860

ccccaccuau ugacauaccc ggugaaguua agaacaugau ggaauuggcu gaaauugaca     1920

ccaugauucc cuuugacuua agugccacga aaaagaacac cauggaaaug uauaggguuc     1980

gguuaaguga caaaccacac acagacgacc ccauacucug ucugucgcuu ucuccagcuu     2040

cagauccuag guugucacau accaugcuag gagaaauccu aaauuacuac acacacuggg     2100

caggaucccu gaaguucacg uuucuguucu guggguccau gauggcaacu ggcaaacugu     2160

uggugucaua cgcgccuccu ggagccgacc caccaaagaa gcguaaggag gcaauguugg     2220

gaacacaugu gaucugggac auaggacugc aauccucaug cacuauggua guaccaugga     2280

uaagcaacac cacguaccgg cagaccauug augauaguuu caccgaaggc ggauacauca     2340

gcgucuucua ccaaaccaga auaguggugc cccuuucgac gcccagggag auggacaucc     2400

uugguuuugu gucagcgugu aaugacuuca gugugcgcuu guugcgagac acuacacaca     2460

uagagcaaaa agcgcuagca cagggguuag gucagaugcu ugaaagcaug auugacaaca     2520

caguccguga gacgaugggg gcggcaacgu cuagagacgc ucucccaaac accgaagcca     2580

guggaccggc acacuccaag gaaaucccgg cacucaccgc aguggaaacu ggggcuacaa     2640

auccacuagu cccuucugac acagugcaaa ccagacaugu uauacaacac aggucuaggu     2700

cagagucuag cauagagucu uucuucgcgc ggggcgcaug cgugaccauc augacuguag     2760

acaacucagc uuccaccaca aacaaggaca agcuauuuuc aguguggaaa aucacguaua     2820

aagacacugu ucaguuacgg aggaaauugg aguuuuucac cuauucuaga uuugauaugg     2880

aauuuaccuu uguagucacu gcaaauuuca cugagacuaa caaugggcau gcuuuaaauc     2940

agguguacca aauuauguac guaccaccag gcgcuccagu gccugagaaa ugggacgacu     3000

acacauggca aaccucauca aacccaucaa uuuuuuacac cuacggaaca gcuccagccc     3060

ggaucucggu accguauguu gguauuucga acgccuauuc acacuuuuac gacgguuuuu     3120

cuaaaguacc acugaaggac cagucggcag cacuaggcga cucccucuau gguguagcau     3180

cucuaaacga uuucgguauu uuggcuguua gaguagucaa ugaucacaac ccgaccaaag     3240

ucaccuccaa agucagagug uaucuaaaac ccaagcacau cagagucugg ugcccgcguc     3300

caccgagggc aguggcguac uacggcccug gaguggauua caaggauggu acgcucacac     3360

cccuuuccac caaggaacug accacauaug gauucggaca ccaaaacaaa gcgguguaca     3420

cugcagguua uaaaauuugc aacuaccauu uggccacuca ggaggauuug caaaacgcag     3480

ugaaugucau guggaacaga gaucuuuuag uuacagaauc aaaagcccag gguacggacu     3540

cgauugccag gugcaguugu aaugcaggag uguauuacug cgaguccaga aggaaauacu     3600

acccaaucuc cuucgucggc cccacuuucc aguauaugga ggccaacgac uacuacccag     3660

cuagauacca aucccauaug uugauugggc auggcuuugc uucgcccggc gauuguggug     3720

guauccucag gugucaacau ggugucauug ggauugugac agcuggugga gaggguuugg     3780

ucgcguucuc ugacauaagg gaccuauaug cuuaugagga ggaagcuaug gagcagggca     3840

uuacaaauua cauugaguca cuuggcgcug cauucgguag cggguucacc cagcaaauag     3900

gggauaagau aucagaacua acuagcaugg uaaccagcac aaucacagag aaacuacuaa     3960

aaaaucuaau caaaauuauu ucaucucugg ugauaaucac cagaaauuau gaagacacua     4020

ccacagugcu ugccacuuua gcucuccuug ggugugacgu uucaccgugg cagugguuga     4080

agaagaaggc augugacauc uuggagauuc ccuauguuau uaaacagggu gauaguuggu     4140

uaaagaaauu cacugaggca uguaacgcag ccaagggguu ggagugggug uccaacaaaa     4200

uuucaaaauu caucgacugg cugaaggaga gaaucauccc acaagccagg gacaagcuug     4260

aauuuguaac caaauugaaa caguuggaaa ugcuugagaa ucaaauaucc acaauacacc     4320

aguccugccc aagucaggaa caccaggaag uuuuauucaa caauguacgc ugguugucca     4380

uccaaucuaa aagauucgcu ccauuauacg cgcucgaagc caagagaaua caaaagcugg     4440

aacacaccau uaauaacuac auacaguuca agagcaaaca ccguauugaa ccaguauguu     4500

uguuggugca ugggagccca ggcacaggga aaucaguugc gaccaaucug auugcuaggg     4560

ccauagcuga gaaagagaac accuccacuu acucacuacc accagauccg ucucacuuug     4620

augguuauaa acaacaaggc gugguuauua uggaugaccu gaaccaaaac ccagacgggg     4680

cagacaugaa gcucuucugu caaauggugu ccacugugga guuuauccca ccuauggccu     4740

cacuggaaga aaagggcauu uuguucacau ccaacuaugu cuuagccucu accaacucca     4800

gucguaucac accacccaca guagcucaca gugacgcgcu ggcccggaga uuugcuuuug     4860

auauggacau acaggugaug ggcgaauacu ccagagaugg uaaacucaau auggcaaugg     4920

cuacagaaau gugcaagaac ugccaccaac cggcaaacuu uaaaagaugc uguccuuuag     4980

uguguggcaa ggcaauucaa uuaauggaca aaucuucuag aguuagauac aguauugauc     5040

agaucacuac aaugauuauc aaugagagaa acagaagauc caacauuggu aauugcaugg     5100

aggcuuuguu ccaaggacca cuccaauaca aagacuugaa aauugauauc aagacgaguc     5160

ccccuccuga auguauuaau gauuugcucc aagcaguuga cucccaggaa gugagggauu     5220

auugcgaaaa gaaagguugg aucgucaaua uuacuaguca agugcaaaca gagagaaaca     5280

ucaaucgagc aaugaccauc uugcaagcag uaacaacuuu ugcugcagug gcuggugucg     5340

uguauguuau guacaaguua uucgcuggac accagggagc auacacuggu cuaccaaaca     5400

aaagacccaa ugugccuacc auuagaacag caaaagugca aggaccuggg uuugacuacg     5460

caguggcuau ggcuaaaaga aacauuguua cagcaacuac uaguaaagga gaguucacaa     5520

ugcugggggu ucaugacaac guggccauuu uaccaacuca ugccucaccu ggugagagua     5580

uugugauuga uggcaaagag guugagauuc uggacgcuaa agcccucgaa gaccaggcag     5640

guacuaaucu ggaaaucacc auaauaaccc ucaaaagaaa ugaaaaauuc agagauauca     5700

gaccacauau acccacucaa aucaccgaga cgaaugaugg aguucugauu gugaacacua     5760

guaaguaccc caauauguau guuccugucg gugcugugac ugagcaggga uaucuaaauc     5820

ucgguggacg ccaaaccgcu cguacuuuaa uguacaacuu uccaaccaga gcagggcagu     5880

gugguggagu caucacaugu acugggaagg ucaucgggau gcauguuggu gggaacgguu     5940

cacacggguu ugcagcggcc cugaagcgau cauacuucac ucagagucaa ggugaaauuc     6000

aguggaugag accaucgaag gaagugggau acccaauuau aaacgccccg uccaaaacca     6060

agcuugaacc cagugcuuuu cacuauguau uugaaggagu gaaggaacca gcaguccuua     6120

ccaaaaacga ucccaggcuu aaaacagacu uugaggaggc aauuuucucc aaguacgugg     6180

gcaacaagau cacugaagug gaugaguaca ugaaagaggc aguagaccac uaugcuggcc     6240

aacucauguc acuagacauu gacacagaac agauguguuu ggaggaugcc auguauggca     6300

cugauggucu ggaagcacuu gauuuaucca ccagugcugg cuacccuuau guaacaaugg     6360

gaaagaagaa aagagauauu uuaaacaaac aaaccaggga caccaaggaa augcaaaaac     6420

ucuuagauac uuauggaauc aauuuaccgu uaguaacgua ugucaaagau gagcuaaggu     6480

cuaaaaccaa aguggagcag ggaaaaucca gauugauuga agccuccagc uuaaaugauu     6540

caguagcuau gagaauggca uuuggaaauc ucuaugcagc auuccauaaa aacccaggag     6600

uuauuacugg cagugcaguu gguugugacc cagaucuguu cuggagcaag auuccaguac     6660

ugauggaaga aaagcuuuuc gccuuugacu auacaggcua ugaugcauca cucagcccag     6720

cuugguuuga ggcacucaaa augguauugg agaaaauugg auucggggac agaguggacu     6780

acauugacua ccucaaucau ucacaccacu uguacaagaa caaaacauac ugugucaagg     6840

gcggcaugcc aucuggcugc ucuggcaccu caaucuucaa cucgaugauc aacaaucuga     6900

ucauuaggac gcuuuugcua aaaaccuaca agggcauaga cuuagaccac cuaaaaauga     6960

uugccuaugg ugaugaugua aucgcuuccu acccccauga gguugacgcu agucuccuag     7020

cccaaucagg aaaagacuau ggacuaacua ugacuccagc agauaaaucu gccacuuuug     7080

aaacagucac augggagaau guaacauuuu ugaaaagauu cuucagagca gacgagaagu     7140

auccauuucu uauucaucca guaaugccaa ugaaggaaau ucaugaauca aucagaugga     7200

ccaaggaucc uagaaacaca caggaucacg uacgcucuuu gugcuuauug gcuuggcaca     7260

auggagaaga agaauacaac aaguuccuag cuaaaauuag gagcgugcca auuggaagag     7320

ccuugcugcu cccagaguac ucaacauugu accgacguug gcucgacucg uuuuaguaac     7380

ccuaccucag ucgaauugga uugggucaua cuguuguagg gguaaauuuu ucuuuaauuc     7440

gggg                                                                  7444


<210>  2
<211>  881
<212>  PRT
<213>  Poliovirus

<400>  2

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ser Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Met Leu Asn Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp 
65                  70                  75                  80  


Arg Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95      


Ala Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Tyr Leu Arg 
            100                 105                 110         


Asp Ser Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala 
        115                 120                 125             


Ala Cys Arg Phe Tyr Thr Leu Asp Thr Val Ser Trp Thr Lys Glu Ser 
    130                 135                 140                 


Arg Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Asn Met Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr 
                165                 170                 175     


Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly 
            180                 185                 190         


Val Phe Ala Val Pro Glu Met Cys Leu Ala Gly Asp Ser Asn Thr Thr 
        195                 200                 205             


Thr Met His Thr Ser Tyr Gln Asn Ala Asn Pro Gly Glu Lys Gly Gly 
    210                 215                 220                 


Thr Phe Thr Gly Thr Phe Thr Pro Asp Asn Asn Gln Thr Ser Pro Ala 
225                 230                 235                 240 


Arg Arg Phe Cys Pro Val Asp Tyr Leu Leu Gly Asn Gly Thr Leu Leu 
                245                 250                 255     


Gly Asn Ala Phe Val Phe Pro His Gln Ile Ile Asn Leu Arg Thr Asn 
            260                 265                 270         


Asn Cys Ala Thr Leu Val Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp 
        275                 280                 285             


Ser Met Val Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala 
    290                 295                 300                 


Pro Leu Asn Phe Ala Ser Glu Ser Ser Pro Glu Ile Pro Ile Thr Leu 
305                 310                 315                 320 


Thr Ile Ala Pro Met Cys Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr 
                325                 330                 335     


Leu Pro Arg Leu Gln Gly Leu Pro Val Met Asn Thr Pro Gly Ser Asn 
            340                 345                 350         


Gln Tyr Leu Thr Ala Asp Asn Phe Gln Ser Pro Cys Ala Leu Pro Glu 
        355                 360                 365             


Phe Asp Val Thr Pro Pro Ile Asp Ile Pro Gly Glu Val Lys Asn Met 
    370                 375                 380                 


Met Glu Leu Ala Glu Ile Asp Thr Met Ile Pro Phe Asp Leu Ser Ala 
385                 390                 395                 400 


Thr Lys Lys Asn Thr Met Glu Met Tyr Arg Val Arg Leu Ser Asp Lys 
                405                 410                 415     


Pro His Thr Asp Asp Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser 
            420                 425                 430         


Asp Pro Arg Leu Ser His Thr Met Leu Gly Glu Ile Leu Asn Tyr Tyr 
        435                 440                 445             


Thr His Trp Ala Gly Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser 
    450                 455                 460                 


Met Met Ala Thr Gly Lys Leu Leu Val Ser Tyr Ala Pro Pro Gly Ala 
465                 470                 475                 480 


Asp Pro Pro Lys Lys Arg Lys Glu Ala Met Leu Gly Thr His Val Ile 
                485                 490                 495     


Trp Asp Ile Gly Leu Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile 
            500                 505                 510         


Ser Asn Thr Thr Tyr Arg Gln Thr Ile Asp Asp Ser Phe Thr Glu Gly 
        515                 520                 525             


Gly Tyr Ile Ser Val Phe Tyr Gln Thr Arg Ile Val Val Pro Leu Ser 
    530                 535                 540                 


Thr Pro Arg Glu Met Asp Ile Leu Gly Phe Val Ser Ala Cys Asn Asp 
545                 550                 555                 560 


Phe Ser Val Arg Leu Leu Arg Asp Thr Thr His Ile Glu Gln Lys Ala 
                565                 570                 575     


Leu Ala Gln Gly Leu Gly Gln Met Leu Glu Ser Met Ile Asp Asn Thr 
            580                 585                 590         


Val Arg Glu Thr Val Gly Ala Ala Thr Ser Arg Asp Ala Leu Pro Asn 
        595                 600                 605             


Thr Glu Ala Ser Gly Pro Thr His Ser Lys Glu Ile Pro Ala Leu Thr 
    610                 615                 620                 


Ala Val Glu Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val 
625                 630                 635                 640 


Gln Thr Arg His Val Val Gln His Arg Ser Arg Ser Glu Ser Ser Ile 
                645                 650                 655     


Glu Ser Phe Phe Ala Arg Gly Ala Cys Val Thr Ile Met Thr Val Asp 
            660                 665                 670         


Asn Pro Ala Ser Thr Thr Asn Lys Asp Lys Leu Phe Ala Val Trp Lys 
        675                 680                 685             


Ile Thr Tyr Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe 
    690                 695                 700                 


Thr Tyr Ser Arg Phe Asp Met Glu Leu Thr Phe Val Val Thr Ala Asn 
705                 710                 715                 720 


Phe Thr Glu Thr Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile 
                725                 730                 735     


Met Tyr Val Pro Pro Gly Ala Pro Val Pro Glu Lys Trp Asp Asp Tyr 
            740                 745                 750         


Thr Trp Gln Thr Ser Ser Asn Pro Ser Ile Phe Tyr Thr Tyr Gly Thr 
        755                 760                 765             


Ala Pro Ala Arg Ile Ser Val Pro Tyr Val Gly Ile Ser Asn Ala Tyr 
    770                 775                 780                 


Ser His Phe Tyr Asp Gly Phe Ser Lys Val Pro Leu Lys Asp Gln Ser 
785                 790                 795                 800 


Ala Ala Leu Gly Asp Ser Leu Tyr Gly Ala Ala Ser Leu Asn Asp Phe 
                805                 810                 815     


Gly Ile Leu Ala Val Arg Val Val Asn Asp His Asn Pro Thr Lys Val 
            820                 825                 830         


Thr Ser Lys Ile Arg Val Tyr Leu Lys Pro Lys His Ile Arg Val Trp 
        835                 840                 845             


Cys Pro Arg Pro Pro Arg Ala Val Ala Tyr Tyr Gly Pro Gly Val Asp 
    850                 855                 860                 


Tyr Lys Asp Gly Thr Leu Thr Pro Leu Ser Thr Lys Asp Leu Thr Thr 
865                 870                 875                 880 


Tyr 
    


<210>  3
<211>  879
<212>  PRT
<213>  Poliovirus

<400>  3

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ala Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Thr Leu Asn Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp 
65                  70                  75                  80  


Arg Val Met Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95      


Ala Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Tyr Ile Lys 
            100                 105                 110         


Asp Ser Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala 
        115                 120                 125             


Ala Cys Arg Phe Tyr Thr Leu Asp Thr Val Thr Trp Arg Lys Glu Ser 
    130                 135                 140                 


Arg Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Lys Asp Met Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Asn Met Phe Tyr His Tyr Leu Gly Arg Ala Gly Tyr Thr 
                165                 170                 175     


Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly 
            180                 185                 190         


Val Phe Ala Val Pro Glu Met Cys Leu Ala Gly Asp Ser Thr Thr His 
        195                 200                 205             


Met Phe Thr Lys Tyr Glu Asn Ala Asn Pro Gly Glu Lys Gly Gly Glu 
    210                 215                 220                 


Phe Lys Gly Ser Phe Thr Leu Asp Thr Asn Ala Thr Asn Pro Ala Arg 
225                 230                 235                 240 


Asn Phe Cys Pro Val Asp Tyr Leu Phe Gly Ser Gly Val Leu Ala Gly 
                245                 250                 255     


Asn Ala Phe Val Tyr Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn 
            260                 265                 270         


Cys Ala Thr Leu Val Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp Ser 
        275                 280                 285             


Met Thr Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala Pro 
    290                 295                 300                 


Leu Asp Phe Ala Thr Glu Ser Ser Thr Glu Ile Pro Ile Thr Leu Thr 
305                 310                 315                 320 


Ile Ala Pro Met Cys Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr Val 
                325                 330                 335     


Pro Arg Thr Gln Gly Leu Pro Val Leu Asn Thr Pro Gly Ser Asn Gln 
            340                 345                 350         


Tyr Leu Thr Ala Asp Asn Tyr Gln Ser Pro Cys Ala Ile Pro Glu Phe 
        355                 360                 365             


Asp Val Thr Pro Pro Ile Asp Ile Pro Gly Glu Val Arg Asn Met Met 
    370                 375                 380                 


Glu Leu Ala Glu Ile Asp Thr Met Ile Pro Leu Asn Leu Thr Asn Gln 
385                 390                 395                 400 


Arg Lys Asn Thr Met Asp Met Tyr Arg Val Glu Leu Asn Asp Ala Ala 
                405                 410                 415     


His Ser Asp Thr Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser Asp 
            420                 425                 430         


Pro Arg Leu Ala His Thr Met Leu Gly Glu Ile Leu Asn Tyr Tyr Thr 
        435                 440                 445             


His Trp Ala Gly Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser Met 
    450                 455                 460                 


Met Ala Thr Gly Lys Leu Leu Val Ser Tyr Ala Pro Pro Gly Ala Glu 
465                 470                 475                 480 


Ala Pro Lys Ser Arg Lys Glu Ala Met Leu Gly Thr His Val Ile Trp 
                485                 490                 495     


Asp Ile Gly Leu Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser 
            500                 505                 510         


Asn Thr Thr Tyr Arg Gln Thr Ile Asn Asp Ser Phe Thr Glu Gly Gly 
        515                 520                 525             


Tyr Ile Ser Met Phe Tyr Gln Thr Arg Val Val Val Pro Leu Ser Thr 
    530                 535                 540                 


Pro Arg Lys Met Asp Ile Leu Gly Phe Val Ser Ala Cys Asn Asp Phe 
545                 550                 555                 560 


Ser Val Arg Leu Leu Arg Asp Thr Thr His Ile Ser Gln Glu Ala Met 
                565                 570                 575     


Pro Gln Gly Leu Gly Asp Leu Ile Glu Gly Val Val Glu Gly Val Thr 
            580                 585                 590         


Arg Asn Ala Leu Thr Pro Leu Thr Pro Ala Asn Asn Leu Pro Asp Thr 
        595                 600                 605             


Gln Ser Ser Gly Pro Ala His Ser Lys Glu Thr Pro Ala Leu Thr Ala 
    610                 615                 620                 


Val Glu Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val Gln 
625                 630                 635                 640 


Thr Arg His Val Ile Gln Lys Arg Thr Arg Ser Glu Ser Thr Val Glu 
                645                 650                 655     


Ser Phe Phe Ala Arg Gly Ala Cys Val Ala Ile Ile Glu Val Asp Asn 
            660                 665                 670         


Asp Ala Pro Thr Lys Arg Ala Ser Lys Leu Phe Ser Val Trp Lys Ile 
        675                 680                 685             


Thr Tyr Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr 
    690                 695                 700                 


Tyr Ser Arg Phe Asp Met Glu Phe Thr Phe Val Val Thr Ser Asn Tyr 
705                 710                 715                 720 


Thr Asp Ala Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met 
                725                 730                 735     


Tyr Ile Pro Pro Gly Ala Pro Ile Pro Gly Lys Trp Asn Asp Tyr Thr 
            740                 745                 750         


Trp Gln Thr Ser Ser Asn Pro Ser Val Phe Tyr Thr Tyr Gly Ala Pro 
        755                 760                 765             


Pro Ala Arg Ile Ser Val Pro Tyr Val Gly Ile Ala Asn Ala Tyr Ser 
    770                 775                 780                 


His Phe Tyr Asp Gly Phe Ala Lys Val Pro Leu Ala Gly Gln Ala Ser 
785                 790                 795                 800 


Thr Glu Gly Asp Ser Leu Tyr Gly Ala Ala Ser Leu Asn Asp Phe Gly 
                805                 810                 815     


Ser Leu Ala Val Arg Val Val Asn Asp His Asn Pro Thr Lys Leu Thr 
            820                 825                 830         


Ser Lys Ile Arg Val Tyr Met Lys Pro Lys His Val Arg Val Trp Cys 
        835                 840                 845             


Pro Arg Pro Pro Arg Ala Val Pro Tyr Tyr Gly Pro Gly Val Asp Tyr 
    850                 855                 860                 


Lys Asp Gly Leu Ala Pro Leu Pro Gly Lys Gly Leu Thr Thr Tyr 
865                 870                 875                 


<210>  4
<211>  878
<212>  PRT
<213>  Poliovirus

<400>  4

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Lys Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Tyr Ser Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Leu Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Thr Leu Asn Ser Pro Asn Val Glu Ala Cys Gly Tyr Ser Asp 
65                  70                  75                  80  


Arg Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95      


Ala Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Phe Ile Arg 
            100                 105                 110         


Asp Asp Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala 
        115                 120                 125             


Thr Cys Arg Phe Tyr Thr Leu Asp Thr Val Met Trp Gly Lys Glu Ser 
    130                 135                 140                 


Lys Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Asn Met Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr 
                165                 170                 175     


Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly 
            180                 185                 190         


Val Phe Ala Ile Pro Glu Tyr Cys Leu Ala Gly Asp Ser Asp Lys Gln 
        195                 200                 205             


Arg Tyr Thr Ser Tyr Ala Asn Ala Asn Pro Gly Glu Lys Gly Gly Lys 
    210                 215                 220                 


Phe Tyr Ser Gln Phe Asn Arg Asp Thr Ala Val Thr Ser Pro Lys Arg 
225                 230                 235                 240 


Glu Phe Cys Pro Val Asp Tyr Leu Leu Gly Cys Gly Val Leu Leu Gly 
                245                 250                 255     


Asn Ala Phe Val Tyr Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn 
            260                 265                 270         


Ser Ala Thr Ile Val Leu Pro Tyr Val Asn Ala Leu Ala Ile Asp Ser 
        275                 280                 285             


Met Val Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ser Pro 
    290                 295                 300                 


Leu Asp Phe Ala Gln Asp Ser Ser Val Glu Ile Pro Ile Thr Val Thr 
305                 310                 315                 320 


Ile Ala Pro Met Cys Ser Glu Phe Asn Gly Leu Arg Asn Val Thr Ala 
                325                 330                 335     


Pro Lys Phe Gln Gly Leu Pro Val Leu Asn Thr Pro Gly Ser Asn Gln 
            340                 345                 350         


Tyr Leu Thr Ser Asp Asn His Gln Ser Pro Cys Ala Ile Pro Glu Phe 
        355                 360                 365             


Asp Val Thr Pro Pro Ile Asp Ile Pro Gly Glu Val Lys Asn Met Met 
    370                 375                 380                 


Glu Leu Ala Glu Ile Asp Thr Met Ile Pro Leu Asn Leu Glu Asn Thr 
385                 390                 395                 400 


Lys Arg Asn Thr Met Asp Met Tyr Arg Val Thr Leu Ser Asp Ser Ala 
                405                 410                 415     


Asp Leu Ser Gln Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser Asp 
            420                 425                 430         


Pro Arg Leu Ser His Thr Met Leu Gly Glu Val Leu Asn Tyr Tyr Thr 
        435                 440                 445             


His Trp Ala Gly Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser Met 
    450                 455                 460                 


Met Ala Thr Gly Lys Ile Leu Val Ala Tyr Ala Pro Pro Gly Ala Gln 
465                 470                 475                 480 


Pro Pro Thr Ser Arg Lys Glu Ala Met Leu Gly Thr His Val Ile Trp 
                485                 490                 495     


Asp Leu Gly Leu Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser 
            500                 505                 510         


Asn Val Thr Tyr Arg Gln Thr Thr Gln Asp Ser Phe Thr Glu Gly Gly 
        515                 520                 525             


Tyr Ile Ser Met Phe Tyr Gln Thr Arg Ile Val Val Pro Leu Ser Thr 
    530                 535                 540                 


Pro Lys Ser Met Ser Met Leu Gly Phe Val Ser Ala Cys Asn Asp Phe 
545                 550                 555                 560 


Ser Val Arg Leu Leu Arg Asp Thr Thr His Ile Ser Gln Ser Ala Leu 
                565                 570                 575     


Pro Gln Gly Ile Glu Asp Leu Ile Thr Glu Val Ala Gln Gly Ala Leu 
            580                 585                 590         


Thr Leu Ser Leu Pro Lys Gln Gln Asp Ser Leu Pro Asp Thr Lys Ala 
        595                 600                 605             


Ser Gly Pro Ala His Ser Lys Glu Val Pro Ala Leu Thr Ala Val Glu 
    610                 615                 620                 


Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val Gln Thr Arg 
625                 630                 635                 640 


His Val Ile Gln Arg Arg Ser Arg Ser Glu Ser Thr Ile Glu Ser Phe 
                645                 650                 655     


Phe Ala Arg Gly Ala Cys Val Ala Ile Ile Glu Val Asp Asn Glu Glu 
            660                 665                 670         


Pro Thr Thr Arg Ala Gln Lys Leu Phe Ala Thr Trp Arg Ile Thr Tyr 
        675                 680                 685             


Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr Tyr Ser 
    690                 695                 700                 


Arg Phe Asp Met Glu Phe Thr Phe Val Val Thr Ala Asn Phe Thr Asn 
705                 710                 715                 720 


Thr Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met Tyr Ile 
                725                 730                 735     


Pro Pro Gly Ala Pro Thr Pro Lys Ser Trp Asp Asp Tyr Thr Trp Gln 
            740                 745                 750         


Thr Ser Ser Asn Pro Ser Ile Phe Tyr Thr Tyr Gly Ala Ala Pro Ala 
        755                 760                 765             


Arg Ile Ser Val Pro Tyr Val Gly Leu Ala Asn Ala Tyr Ser His Phe 
    770                 775                 780                 


Tyr Asp Gly Phe Ala Lys Val Pro Leu Lys Thr Asp Ala Asn Asp Gln 
785                 790                 795                 800 


Ile Gly Asp Ser Leu Tyr Ser Ala Met Thr Val Asp Asp Phe Gly Val 
                805                 810                 815     


Leu Ala Ile Arg Val Val Asn Asp His Asn Pro Thr Lys Val Thr Ser 
            820                 825                 830         


Lys Val Arg Ile Tyr Met Lys Pro Lys His Val Arg Val Trp Cys Pro 
        835                 840                 845             


Arg Pro Pro Arg Ala Val Pro Tyr Tyr Gly Pro Gly Val Asp Tyr Lys 
    850                 855                 860                 


Asp Asn Leu Asn Pro Leu Ser Glu Lys Gly Leu Thr Thr Tyr 
865                 870                 875             


<210>  5
<211>  7502
<212>  RNA
<213>  Poliovirus

<400>  5
uuaaaacagc ucugggguug uucccacccc agaggcccac guggcggcca guacacuggu       60

auugcgguac cuuuguacgc cuguuuuaua cucccuuccc ccguaacuua gaagcacaau      120

guccaaguuc aauaggaggg gguacaaacc aguaccacca cgaacaagca cuucuguucc      180

cccggugagg cuguauaggc uguuuccacg gcuaaaagcg gcugauccgu uauccgcuca      240

uguacuucga gaagccuagu aucaccuugg aaucuucgau gcguugcgcu caacacucaa      300

ccccagagug uagcuuaggu cgaugagucu ggacguuccu caccggcgac ggugguccag      360

gcugcguugg cggccuaccu guggcccaaa gccacaggac gcuaguugug aacaaggugu      420

gaagagccua uugagcuacc ugagaguccu ccggccccug aaugcggcua auccuaacca      480

cggagcaggc aguggcaauc cagcgaccag ccugucguaa cgcgcaaguu cguggcggaa      540

ccgacuacuu uggguguccg uguuuccuuu uauuuuuaca auggcugcuu auggugacaa      600

ucauugauug uuaucauaaa gcaaauugga uuggccaucc ggugagaauu ugauuauuaa      660

auuacucucu uguugggauu gcuccuuuga aauccugugc acucacaccu auuggaauua      720

ccucauuguu aagauaucau caccacuaug ggcgcccaag ucucaucaca gaaaguugga      780

gcccaugaga auucaaacag agcuuauggc ggauccacca uuaauuacac uacuauuaau      840

uauuacaggg auucugcgag caaugccgcu aguaagcagg acuuugcaca agacccaucc      900

aaguucacug aaccuauuaa agauguucuc auuaagaccg cucccacgcu aaacucuccu      960

aauaucgagg cgugugggua uagcgacaga gugaugcaac uaacccuagg caauuccacc     1020

auuaccacac aggaggcggc caauucuguc guugcauacg gccgguggcc cgaguacauc     1080

aaggacucag aagcaaaucc uguggaccag ccaacugaac cggacguugc cgcgugcagg     1140

uuuuacacac uagacacugu uacuuggcgc aaggagucca gaggguggug guggaaacug     1200

ccugaugcac uaaaggacau gggauuauuc ggccagaaca uguucuacca cuaccucggg     1260

agggcuggcu auacugugca cguacagugu aaugcuucaa aguuucacca gggcgcccuc     1320

gggguauucg caguuccaga aaugugccug gcaggcgaca gcacaaccca cauguuuaca     1380

aaauaugaga augcaaaucc gggugagaaa gggggugaau ucaaagggag uuuuacucug     1440

gauacuaacg cuaccaaccc ugcacgcaac uuuugucccg uugauuaucu cuucgggagc     1500

ggaguacugg cgggaaaugc guuuguuuac ccacaucaga uaauuaaucu gcgcaccaac     1560

aacugugcca cguuggugcu gccauacguu aauucacuuu ccauagacag caugacaaaa     1620

cacaacaauu ggggaauugc uauccuuccg cuggcaccac uugacuuugc caccgagucc     1680

uccacugaga uacccauuac ucuaacuauu gccccuaugu guugugaauu caauggguug     1740

cgcaacauca cuguacccag aacucaaggg uugccagucu uaaacacucc aggaagcaac     1800

caguacuuaa cagcagacaa cuaucaaucc ccaugugcga uacccgaguu ugauguaaca     1860

ccacccauag acaucccggg ggaagugcgc aacaugaugg aauuggcaga gauagacacc     1920

augauaccuc ucaaucugac gaaccagcgc aagaacacca uggauaugua cagagucgaa     1980

cugaaugaug cggcucacuc ugacacacca auauuguguc ucucacuguc uccagcauca     2040

gauccuaggc uagcacacac uaugcuaggu gaaauacuga acuacuacac acacugggca     2100

gggucauuga aguucacauu ucucuucugc ggcucaauga uggccacugg uaaauugcua     2160

guguccuaug caccuccugg ugcggaagcc ccuaaaagcc gcaaagaagc gaugcucggc     2220

acccacguga ucugggacau cggauuacag ucaucaugca cuaugguggu accuuggauu     2280

agcaacacca cauacagaca aaccaucaac gauagcuuca cagaaggagg guacaucagu     2340

auguuuuacc aaacuagagu uguugugcca uuguccaccc cuagaaagau ggacauauug     2400

ggcuuugugu cagccugcaa ugacuucagu gugcgccugu ugcgugacac gacgcacaua     2460

agccaagagg cuaugccaca aggauugggu gauuuaauug aagggguugu ugagggaguc     2520

acgagaaaug ccuugacacc acugacaccu gccaacaacu ugccugauac acaaucuagc     2580

ggcccagccc acucuaagga aacaccagcg cuaacagccg uagagacagg ggccaccaac     2640

ccauuggugc cuucagacac gguacaaacu cgucacguca uccaaaagcg gacgcggucg     2700

gagucuacgg uugagucuuu cuucgcaaga ggagcuugug uggccauuau ugaaguggau     2760

aaugaugcuc caacaaagcg ugccaguaaa uuauuuucag ucuggaagau aacuuacaaa     2820

gacaccguuc aguuaagacg uaaguuggag uucuuuacau auucaagguu ugacauggag     2880

uucaccuuug ugguuacauc caauuauacc gaugcaaaca augggcacgc acuaaaucaa     2940

guuuaccaga uaauguacau accaccuggg gcaccgaucc cuggcaagug gaaugauuac     3000

acauggcaaa cgucaucuaa cccaucagug uuuuacacuu acggggcacc uccagcuaga     3060

auaucagugc ccuacguggg cauugccaau gcauauucuc auuuuuacga uggguuugcc     3120

aaaguaccac uagcaggcca agccucaaca gagggugacu cgcuguaugg agcggcuuca     3180

uugaaugacu ucggaucacu ggcuguucga guggugaaug accacaaccc uacgaaacuc     3240

acuucaaaaa ucagagugua caugaaacca aagcacguca gaguguggug uccgcgaccc     3300

ccucgagcag ucccauacua cggaccaggg guugacuaca aggauggacu agccccacug     3360

ccagggaaag gcuugacaac cuaugguuuu ggccaccaaa auaaggcagu guacacggca     3420

gguuacaaaa uuugcaauua ccaccucgcc acccaggaag acuuacaaaa ugcgguaaac     3480

auuaugugga uuagagaccu uuuaguagug gaauccaaag cccaaggcau agacacaauu     3540

gcuagaugua acugccacac uggaguguac uacugugaau ccaggaggaa guacuacccg     3600

gucucuuuua cuggccccac cuuucaguac auggaagcaa augaguacua uccagcccga     3660

uaccaauccc acauguuaau uggccauggu uuugcaucuc caggggacug uggugggauu     3720

cucaggugcc aacauggagu aauuggaauc auuacagcug gaggagaagg ccuagucgcu     3780

uucgcggaca ucagagaucu guacgcauac gaggaggagg cuauggagca gggagucucc     3840

aacuauauug agucccuugg ggcugcauuu gggaguggau ucacucagca aauaggaaac     3900

aaaauuucag aacucacuag cauggucacc agcacuauaa cugagaaacu acuaaagaau     3960

cucauuaaaa uaauuucauc ccuuguuauc aucaccagaa acuaugaaga cacgaccaca     4020

gugcuggcua cccuugcucu ccucgguugu gaugcguccc cauggcaaug gcuaaagaag     4080

aaagccugug acaucuugga aauccccuac aucaugcgac agggcgauag cugguugaag     4140

aaguuuacag aggcaugcaa ugcagccaag ggauuggaau gggugucuaa uaaaauaucc     4200

aaauuuauug acuggcucaa agagaagauc auuccacagg cuagagacaa gcuagaguuu     4260

guuaccaaac ugaagcaacu agaaauguug gagaaccaaa uugcaaccau ucaucaaucg     4320

ugcccaaguc aggagcauca agaaauccug uucaauaacg ugagaugguu auccauacag     4380

ucaaagagau uugccccgcu cuaugcgguu gaggcuaaga gaauacaaaa guuagagcac     4440

acgauuaaca acuacguaca guucaagagc aaacaccgua uugaaccagu auguuuguug     4500

gugcacggua gcccaggcac gggcaaguca guugccacca auuuaauugc cagagcaaua     4560

gcagagaagg agaacaccuc cacauacuca cuaccaccag aucccuccca uuucgauggg     4620

uacaagcaac aagguguggu gaucauggau gauuugaauc agaacccaga cggagcagac     4680

augaagcugu uuugucagau ggucuccacu guagaauuca uaccaccaau ggcuucgcua     4740

gaagaaaagg guauuuuguu cacaucuaau uacguuuugg ccucaaccaa uuccagucgc     4800

aucaccccac caacuguugc gcacagcgau gcccuagcca ggcgcuuugc auuugacaug     4860

gacauacaaa ucaugagcga guauucuaga gauggaaaau ugaacauggc gauggcaacu     4920

gaaaugugua agaacuguca ucaaccagca aacuucaaga gauguugccc auuggugugu     4980

ggcaaagcca uccagcugau ggacaaaucu uccagaguca gauauaguau agaucagauu     5040

acuaccauga uuauuaauga gaggaacaga agaucaagua ucgguaauug cauggaggca     5100

cuuuuccaag guccucuuca auacaaagac cugaaaauag acauuaagac cacaccuccu     5160

ccugagugca ucaaugauuu gcuccaagca guugauucuc aagagguaag agacuacugu     5220

gagaagaagg guuggauagu agacaucacu agucaggugc aaaccgaaag aaacaucaau     5280

agagcaauga cuauucuuca ggcggucacc acauuugccg caguugcugg agugguguau     5340

gugauguaca aacucuuugc agggcaucaa ggagcguaua cagggcuucc caauaagaga     5400

cccaaugucc ccaccaucag gacugccaag guucagggcc caggauuuga cuacgcagug     5460

gcaauggcca aaagaaacau ucuuacggca acuaccauua agggagaguu cacaaugcuc     5520

ggagugcaug auaauguggc cauucuacca acccacgcau caccggguga aacaauaguc     5580

auugauggca aggaaguaga gguacuggau gcuaaagccc uggaggacca ggccgggacc     5640

aaccuagaaa ucaccaucgu cacucuuaag agaaaugaga aguucaggga caucagacca     5700

cacaucccca cucaaaucac ugagacaaau gauggaguuu uaauugugaa cacuaguaag     5760

uaccccaaca uguauguucc ugucggugcu gugacugaac agggguaucu caaucucggu     5820

ggacgccaaa cugcucguac uuuaauguac aacuuuccaa cgagagcagg ucaauguggu     5880

ggaguuauca ccugcacugg caaggucauc gggaugcaug uuggugggaa cgguucacau     5940

ggguucgcag cagcccugaa gcgauccuau uucacucaga gucaagguga aauccagugg     6000

augagaccau caaaagaagu gggcuacccc guuauuaaug cuccaucuaa aacuaaacug     6060

gaacccagug cauuccauua uguguuugaa ggugucaagg aaccagcugu gcucaccaaa     6120

agugacccca gauugaagac agauuuugaa gaggcuaucu uuuccaagua ugugggaaau     6180

aagauuacug aaguggauga guacaugaaa gaagcugucg aucauuacgc aggccagcuc     6240

augucacuag acaucaacac agaacaaaug ugccuugagg augcaaugua uggcacugac     6300

ggucucgaag cucuagaccu caguaccagu gcuggguauc ccuauguggc aauggggaaa     6360

aagaaaagag acauuuugaa uaagcaaacc agagacacaa aggaaaugca aaggcuucug     6420

gacaccuaug guauuaauuu accuuuaguc accuauguga aagaugagcu uagauccaag     6480

accaaagugg aacagggcaa guccaggcua auugaggccu caagucucaa ugacucuguc     6540

gccaugagga uggcuuuugg caacuuguac gcagcauucc acaagaaccc agguguagug     6600

acaggaucgg cuguuggcug ugacccagau uuguuuugga guaaaauacc aguccucaug     6660

gaggaaaaac ucuuugcauu ugauuacacg gguuaugaug cuucacuaag ccccgccugg     6720

uuugaggcuc ucaagauggu ucuagagaaa auuggguuug gugacagagu ggauuacauu     6780

gauuaucuga aucacucgca ccaucuauau aaaaauaaga cauauugugu uaagggcggc     6840

augccaucug gcugcucugg caccucaauu uuuaauucaa ugauuaauaa ucuaauaauc     6900

aggacucucu uacugaaaac cuacaagggc auagauuuag accaccugaa gaugauagcc     6960

uauggugaug auguaauugc uuccuacccc caugagguug augcuagucu ccuagcccaa     7020

ucaggaaaag acuauggacu aaccaugaca ccagcugaca aaucagccac cuuugaaaca     7080

gucacauggg agaauguaac auucuugaaa agauucuuua gagcagauga aaaguauccc     7140

uuucugauac auccagugau gccaaugaaa gaaauucacg aaucaauuag auggacuaaa     7200

gaucccagaa acacucagga ucauguucgc ucacugugcu uauuggcuug gcacaauggc     7260

gaggaagagu acaauaaauu uuuagcuaag auuagaagug ugccaaucgg aagagcauua     7320

cugcucccug aguacuccac auuguaccgc cguuggcucg acucauuuua guaacccuac     7380

cucagucgaa uuggauuggg ucauacuguu guagggguaa auuuuucuuu aauucggaga     7440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     7500

aa                                                                    7502


<210>  6
<211>  7440
<212>  RNA
<213>  Poliovirus

<400>  6
uuaaaacagc ucugggguug uacccacccc agaggcccac guggcggcua guacuccggu       60

auugcgguac ccuuguacgc cuguuuuaua cucccuuccc guaacuuaga cgcacaaaac      120

caaguucaau agaagggggu acaaaccagu accaccacga acaagcacuu cuguuucccc      180

ggugaugucg uauagacugc uugcgugguu gaaagcgacg gauccguuau ccgcuuaugu      240

acuucgagaa gcccaguacc accucggaau cuucgaugcg uugcgcucag cacucaaccc      300

cagaguguag cuuaggcuga ugagucugga caucccucac cggugacggu gguccaggcu      360

gcguuggcgg ccuaccuaug gcuaacgcca ugggacgcua guugugaaca aggugugaag      420

agccuauuga gcuacauaag aauccuccgg ccccugaaug cggcuaaucc caaccucgga      480

gcaggugguc acaaaccagu gauuggccug ucguaacgcg caaguccgug gcggaaccga      540

cuacuuuggg uguccguguu uccuuuuauu uuauuguggc ugcuuauggu gacaaucaca      600

gauuguuauc auaaagcgaa uuggauuggc cauccgguga aagugagacu cauuaucuau      660

cuguuugcug gauccgcucc auugagugug uuuacucuaa guacaauuuc aacaguuauu      720

ucaaucagac aauuguauca uaaugggugc ucagguuuca ucacagaaag ugggcgcaca      780

ugaaaacuca aauagagcgu auggugguuc uaccauuaau uacaccacca uuaauuauua      840

uagagauuca gcuaguaacg cggcuucgaa acaggacuuc ucucaagacc cuuccaaguu      900

caccgagccc aucaaggaug uccugauaaa aacagcccca augcuaaacu cgccaaacau      960

agaggcuugc ggguauagcg auagaguacu gcaauuaaca cugggaaacu ccacuauaac     1020

cacacaggag gcggcuaauu caguagucgc uuaugggcgu uggccugaau aucugaggga     1080

cagcgaagcc aauccagugg accagccgac agaaccagac gucgcugcau gcagguuuua     1140

uacgcuagac accgugucuu ggacgaaaga gucgcgaggg ugguggugga aguugccuga     1200

ugcacugagg gacaugggac ucuuugggca aaauauguac uaccacuacc uagguagguc     1260

cggguacacc gugcauguac aguguaacgc cuccaaauuc caccaggggg cacuaggggu     1320

auucgccgua ccagagaugu gucuggccgg ggauagcaac accacuacca ugcacaccag     1380

cuaucaaaau gccaauccug gcgagaaagg aggcacuuuc acggguacgu ucacuccuga     1440

caacaaccag acaucaccug cccgcagguu cugcccggug gauuaccucc uuggaaaugg     1500

cacguuguug gggaaugccu uuguguuccc gcaccagaua auaaaccuac ggaccaacaa     1560

cugugcuaca cugguacucc cuuacgugaa cucccucucg auagauagua ugguaaagca     1620

caauaauugg ggaauugcaa uauuaccauu ggccccauua aauuuugcua gugaguccuc     1680

cccagagauu ccaaucaccu ugaccauagc cccuaugugc ugugaguuca auggauuaag     1740

aaacaucacc cugccacgcu uacagggccu gccggucaug aacaccccug guagcaauca     1800

auaucuuacu gcagacaacu uccagucacc gugugcgcug ccugaauuug augugacccc     1860

accuauugac auacccggug aaguaaagaa caugauggaa uuggcagaaa ucgacaccau     1920

gauucccuuu gacuuaagug ccacaaaaaa gaacaccaug gaaauguaua ggguucgguu     1980

aagugacaaa ccacauacag acgaucccau acucugccug ucacucucuc cagcuucaga     2040

uccuagguug ucacauacua ugcuuggaga aauccuaaau uacuacacac acugggcagg     2100

aucccugaag uucacguuuc uguucugugg auucaugaug gcaacuggca aacuguuggu     2160

gucauacgcg ccuccuggag ccgacccacc aaagaagcgu aaggaggcga uguugggaac     2220

acaugugauc ugggacauag gacugcaguc cucauguacu augguagugc cauggauuag     2280

caacaccacg uaucggcaaa ccauagauga uaguuucacc gaaggcggau acaucagcgu     2340

cuucuaccaa acuagaauag ucgucccucu uucgacaccc agagagaugg acauccuugg     2400

uuuuguguca gcguguaaug acuucagcgu gcgcuuguug cgagauacca cacauauaga     2460

gcaaaaagcg cuagcacagg gguuagguca gaugcuugaa agcaugauug acaacacagu     2520

ccgugaaacg gugggggcgg caacaucuag agacgcucuc ccaaacacug aagccagugg     2580

accaacacac uccaaggaaa uuccggcacu caccgcagug gaaacugggg ccacaaaucc     2640

acuagucccu ucugauacag ugcaaaccag acauguugua caacauaggu caaggucaga     2700

gucuagcaua gagucuuucu ucgcgcgggg ugcaugcgug accauuauga ccguggauaa     2760

cccagcuucc accacgaaua aggauaagcu auuugcagug uggaagauca cuuauaaaga     2820

uacuguccag uuacggagga aauuggaguu cuucaccuau ucuagauuug auauggaacu     2880

uaccuuugug guuacugcaa auuucacuga gacuaacaau gggcaugccu uaaaucaagu     2940

guaccaaauu auguacguac caccaggcgc uccagugccc gagaaauggg acgacuacac     3000

auggcaaacc ucaucaaauc caucaaucuu uuacaccuac ggaacagcuc cagcccggau     3060

cucgguaccg uauguuggua uuucgaacgc cuauucacac uuuuacgacg guuuuuccaa     3120

aguaccacug aaggaccagu cggcagcacu aggugacucc cuuuauggug cagcaucucu     3180

aaaugacuuc gguauuuugg cuguuagagu agucaaugau cacaacccga ccaaggucac     3240

cuccaaaauc agaguguauc uaaaacccaa acacaucaga gucuggugcc cgcguccacc     3300

gagggcagug gcguacuacg gcccuggagu ggauuacaag gaugguacgc uuacaccccu     3360

cuccaccaag gaucugacca cauauggauu cggacaccaa aacaaagcgg uguacacugc     3420

agguuacaaa auuugcaacu accacuuggc cacucaggau gauuugcaaa acgcagugaa     3480

cgucaugugg aguagagacc ucuuagucac agaaucaaga gcccagggca ccgauucaau     3540

cgcaaggugc aauugcaacg caggggugua cuacugcgag ucuagaagga aauacuaccc     3600

aguauccuuc guuggcccaa cguuccagua cauggaggcu aauaacuauu acccagcuag     3660

guaccagucc cauaugcuca uuggccaugg auucgcaucu ccaggggauu gugguggcau     3720

acucagaugu caccacgggg ugauagggau cauuacugcu gguggcgaag gguugguugc     3780

auuuucagac auuagagacu uguaugccua cgaagaagaa gccauggaac aaggcaucac     3840

caauuacaua gagucacuug gggccgcauu uggaagugga uuuacucagc agauuagcga     3900

caaaauaaca gaguugacca auauggugac caguaccauc acugaaaagc uacuuaagaa     3960

cuugaucaag aucauauccu cacuaguuau uauaacuagg aacuaugaag acaccacaac     4020

agugcucgcu acccuggccc uucuugggug ugaugcuuca ccauggcagu ggcuuagaaa     4080

gaaagcaugc gauguucugg agauaccuua ugucaucaag caaggugaca guugguugaa     4140

gaaguuuacu gaagcaugca acgcagcuaa gggacuggag ugggugucaa acaaaaucuc     4200

aaaauucauu gauuggcuca aggagaaaau uaucccacaa gcuagagaua aguuggaauu     4260

uguaacaaaa cuuagacaac uagaaaugcu ggaaaaccaa aucucaacua uacaccaauc     4320

augcccuagu caggaacacc aggaaauucu auucaauaau gucagauggu uauccaucca     4380

gucuaagagg uuugccccuc uuuacgcagu ggaagccaaa agaauacaga aacuagagca     4440

uacuauuaac aacuacauac aguucaagag caaacaccgu auugaaccag uauguuugcu     4500

aguacauggc agccccggaa cagguaaauc uguagcaacc aaccugauug cuagagccau     4560

agcugaaaga gaaaacacgu ccacguacuc gcuacccccg gauccaucac acuucgacgg     4620

auacaaacaa cagggagugg ugauuaugga cgaccugaau caaaacccag auggugcgga     4680

caugaagcug uucugucaga ugguaucaac aguggaguuu auaccaccca uggcaucccu     4740

ggaggagaaa ggaauccugu uuacuucaaa uuacguucua gcauccacaa acucaagcag     4800

aauuuccccc cccacugugg cacacaguga ugcauuagcc aggcgcuuug cguucgacau     4860

ggacauucag gucaugaaug aguauucuag agaugggaaa uugaacaugg ccauggcuac     4920

ugaaaugugu aagaacuguc accaaccagc aaacuuuaag agaugcuguc cuuuagugug     4980

ugguaaggca auucaauuaa uggacaaauc uuccagaguu agauacagua uugaccagau     5040

cacuacaaug auuaucaaug agagaaacag aagauccaac auuggcaauu guauggaggc     5100

uuuguuucaa ggaccacucc aguauaaaga cuugaaaauu gacaucaaga cgaguccccc     5160

uccugaaugu aucaaugacu ugcuccaagc aguugacucc caggagguga gagauuacug     5220

ugagaagaag gguuggauag ucaacaucac cagccagguu caaacagaaa ggaacaucaa     5280

cagggcaaug acaauucuac aagcggugac aaccuucgcc gcaguggcug gaguugucua     5340

ugucauguau aaacuguuug cuggacacca gggagcauac acugguuuac caaacaaaaa     5400

acccaacgug cccaccauuc ggacagcaaa gguacaagga ccaggguucg auuacgcagu     5460

ggcuauggcu aaaagaaaca uuguuacagc aacuacuagc aagggagagu ucacuauguu     5520

aggaguccac gacaacgugg cuauuuuacc aacccacgcu ucaccuggug aaagcauugu     5580

gaucgauggc aaagaagugg agaucuugga ugccaaagcg cucgaagauc aagcaggaac     5640

caaucuugaa aucacuauaa ucacucuaaa gagaaaugaa aaguucagag acauuagacc     5700

acauauaccu acucaaauca cugagacaaa ugauggaguc uugaucguga acacuagcaa     5760

guaccccaau auguauguuc cugucggugc ugugacugaa cagggauauc uaaaucucgg     5820

ugggcgccaa acugcucgua cucuaaugua caacuuucca accagagcag gacagugugg     5880

uggagucauc acauguacug ggaaagucau cgggaugcau guugguggga acgguucaca     5940

cggguuugca gcggcccuga agcgaucaua cuucacucag agucaaggug aaauccagug     6000

gaugagaccu ucgaaggaag ugggauaucc aaucauaaau gccccgucca aaaccaagcu     6060

ugaacccagu gcuuuccacu auguguuuga aggggugaag gaaccagcag uccucacuaa     6120

aaacgauccc aggcuuaaga cagacuuuga ggaggcaauu uucuccaagu acguggguaa     6180

caaaauuacu gaaguggaug aguacaugaa agaggcagua gaccacuaug cuggccagcu     6240

caugucacua gacaucaaca cagaacaaau gugcuuggag gaugccaugu auggcacuga     6300

uggucuagaa gcacuugauu uguccaccag ugcuggcuac ccuuauguag caaugggaaa     6360

gaagaagaga gacaucuuga acaaacaaac cagagacacu aaggaaaugc aaaaacugcu     6420

cgacacauau ggaaucaacc ucccacuggu gacuuaugua aaggaugaac uuagauccaa     6480

aacaaagguu gagcagggga aauccagauu aauugaagcu ucuaguuuga augacucagu     6540

ggcaaugaga auggcuuuug ggaaccuaua ugcugcuuuu cacaaaaacc caggagugau     6600

aacagguuca gcaguggggu gcgauccaga uuuguuuugg agcaaaauuc cgguauugau     6660

ggaagagaag cuguuugcuu uugacuacac aggguaugau gcaucucuca gcccugcuug     6720

guucgaggca cuaaagaugg ugcuugagaa aaucggauuc ggagacagag uugacuacau     6780

cgacuaccua aaccacucac accaccugua caagaauaaa acauacugug ucaagggcgg     6840

uaugccaucu ggcugcucag gcacuucaau uuuuaacuca augauuaaca acuugauuau     6900

caggacacuc uuacugaaaa ccuacaaggg cauagauuua gaccaccuaa aaaugauugc     6960

cuauggugau gauguaauug cuuccuaccc ccaugaaguu gacgcuaguc uccuagccca     7020

aucaggaaaa gacuauggac uaacuaugac uccagcugac aaaucagcua cauuugaaac     7080

agucacaugg gagaauguaa cauucuugaa gagauucuuc agggcagacg agaaauaccc     7140

auuucuuauu cauccaguaa ugccaaugaa ggaaauucau gaaucaauua gauggacuaa     7200

agauccuagg aacacucagg aucacguucg cucucugugc cuuuuagcuu ggcacaaugg     7260

cgaagaagaa uauaacaaau uccuagcuaa aaucaggagu gugccaauug gaagagcuuu     7320

auugcuccca gaguacucaa cauuguaccg ccguuggcuu gacucauuuu aguaacccua     7380

ccucagucga auuggauugg gucauacugu uguaggggua aauuuuucuu uaauucggag     7440


<210>  7
<211>  7471
<212>  RNA
<213>  Poliovirus

<400>  7
uuaaaacagc ucugggguug uacccacccc agaggcccac guggcggcua guacuccggu       60

accacgguac ccuuguacgc cuguuuuaua cucccuuccc ccgcaauuua gaagcucaug      120

aucaaguuca auaggagggg guacaaacca guaccaccac gaacaagcac uucuguuucc      180

ccggugaugu uguauagacu gcucgcgcgg uuaaaagcga cggauccguu auccgcucau      240

guacuucgag aagccuagua uuaccucggg aucuucgacg cguugcgcuc agcacucaac      300

cccagagugu agcuuagguc gaugagucug gacauuccuc accggcgacg gugguccagg      360

cugcguuggc ggccuaccua uggcuaacgc cauaggacgc uaguugugaa caagguguga      420

agagccuauu gagcuacaug agaguccucc ggccccugaa ugcggcuaau cccaaccucg      480

gagcaggcga ucacaagcca gugauuggcc ugucguaaug cguaaguccg agacggaacc      540

gacuacuuug gguguccgug uuuccuuuua uuuuuaucau ggcugccuau ggugacaauc      600

agugauuguu gucauagagc gaauuggauu ggccauccgg ugaaaacaaa gucaauuacu      660

uucucacuug uuggaccuac acccgauacg cuuuaccccc aagcuaauua aaauuauuag      720

aaguuaggac uacgguguca caaugggagc ucaaguuucg ucccaaaaag uaggcgcuca      780

ugaaaauucc aaccgggccu ccgguggcuc caccaucaac uacaccacaa uuaauuauua      840

uaaagauucu gcuaguaaug cggcgucuaa gcaagacuac ucacaggacc cuucaaaguu      900

caccgagccg cuaaaggaug ugcucauaaa gacagcucca gcacucaauu caccaaaugu      960

ggaggcgugc ggguauagcg auagaguguu acaacucacu uuaggcaauu ccaccauuac     1020

uacacaggag gcagccaacu caguaguagc cuacggacgg uggccugaau ucauuagaga     1080

ugaugaagca aacccagugg aucaaccaac ugagccagac guugccacau gcagauuuua     1140

cacucuagac acuguaaugu ggggcaagga guccaaaggu ugguggugga aguugccuga     1200

ugcacugaga gacauggguc uguuuggaca aaacauguau uaccacuacc uaggaagauc     1260

uggguacacu gugcacgugc agugcaacgc uucuaaauuu caucaaggcg cacuaggggu     1320

guuugcgauu ccugaruauu gucuggcagg cgacagugac aagcaaaggu acacuaguua     1380

ugcaaaugca aauccaggcg aaaagggagg gaaauuuuac ucccaguuca acaaggauaa     1440

cgcaguaacg uccccaaaaa gagaguuuug cccaguggau uaucuccugg gaugcggggu     1500

guugcuggga aaugccuuug uauacccaca ccagaucauu aaucugagga ccaauaacag     1560

cgcaaccauu guccuaccau acgugaaugc uuuagcuauu gacucaaugg uuaaacacaa     1620

caacuggggc auugccauuu ugcccuuauc accguuggac uuugcucagg auucaucagu     1680

ugaaauuccg auuaccguga caauugcccc aauguguagu gaguucaaug gucuccgcaa     1740

cgugacugca cccaaauuuc aaggrcuacc agugcugaau acaccuggaa guaaccagua     1800

ccuaacauca gacaaccacc aaucaccaug cgcaaucccu gaauuugaug ucacuccgcc     1860

uaucgauauc ccaggygagg uuaaaaacau gauggagcuc gccgagauag acaccaugau     1920

cccccucaau uuggagaaua cuaagagaaa uacaauggac auguacaggg ucacucugag     1980

cgacagugcc gaucuaucgc aaccaauucu gugcuugucg cuaucuccgg caucugaucc     2040

gcgcuugucg cacaccaugc uuggggaagu gcugaacuau uauacucauu gggcuggauc     2100

uuugaaguuc acuuuucugu ucuguggcuc aaugauggcu acagggaaaa ucuuaguggc     2160

cuaugcacca ccgggcgcac aaccccccac cagucguaag gaggccaugu ugggcacaca     2220

ucucauuugg gaucuugguc ugcaaucauc cugcaccaug gugguaccau ggauuagcaa     2280

cgugacauac agacagacua cacaagauag cuucacugaa ggcggauaua uuagcauguu     2340

uuaccaaaca aggauuguag ugccacuauc cacccccaag aguaugaaca ugcugggguu     2400

ugugucagcc uguaacgacu uuagugugcg auugcuacga gacaccacuc acauuucaca     2460

aucagcgcuu ccacagggca uugaagaauu gauuuccgaa gucgcgcaag gcgcccuaac     2520

uuuaucacuc cccaagcagc aggacagcuu accugacacc aaggccagug gcccggcgca     2580

cuccaaggag gugccugcac ucacugcagu cgagacuggg gcuaccaauc cucugguacc     2640

auccgacaca guucaaacgc gccauguaau ccaacggcgu agcaggucag aguccacgau     2700

agaaucauuc uucgcacgcg gggcgugcgu ugcuaucauu gagguagaca acgaacaacc     2760

aaccacccgg gcacagaaac uuuuugccac guggcgcauu acguacaaag auacaguaca     2820

auuacgccgc aaauuggagu ucuuuacaua cucccguuuu gacauggaau ucaccuuugu     2880

aguaacugcu aacuucacca acgccaauaa cgggcaugcc cugaaccaag uguaccagau     2940

aauguacauc cccccaggag caccuacacc aaagucaugg gacgacuaca ccuggcaaac     3000

aucuuccaac ccgucuauau ucuacaccua uggggcugca ccggcgcgaa uuucaguacc     3060

auacgugggg uuggccaaug cuuacucaca cuuuuacgac ggcuuugcca aggugccacu     3120

gaaaacagac gccaacgacc aaauugguga uuccuuguac agugcuauga caguggacga     3180

cuuuggugug uuggcaauuc gaguugucaa ugaucacaac cccacuaarg uaaccuccaa     3240

aauccgcauu uacaugaaac ccaaacacgu gcgugucugg ugcccuagac caccacgcgc     3300

gguaccuuuu uauggaccag ggguggacua caaagacaac uugaaccccu ugucugygaa     3360

agguuugacc accuauggcu uuggacauca gaauaaggcu guuuauaccg cuggauacaa     3420

gauuuguaac uaucaccuug cuacccaaga ggaucuacaa aaugcugugu guaucaugug     3480

gaacagagau cuugugguug uugauucaaa agcucaaggc accgacucga uagcuagaug     3540

uaacugcaac gcaggggugu auuacuguga guccaggaga aaauacuacc cugugucauu     3600

cauaggaccc accuuucagu uuauggaggc caaugacuau uacccugcaa gguaucaguc     3660

ccacauguua auugggcacg guuuugccuc accaggcgau uguggcggca uucuuagaug     3720

ccagcauggc guuauuggga uuauaacagc ugguggugaa ggcuuggucg cauuuucaga     3780

cauaagagau cuuuaugcau augaagagga agcuauggag cagggaauau ccaauuacau     3840

agagucgcuc ggagcagcgu ucggcagcgg guuuacucag caaauagggg acaagaucuc     3900

agagcugacu agcaugguga ccagcacaau uacggagaaa uuacuaaaga accuaaucaa     3960

gaucaucuca ucacugguga ucauaaccag aaacuacgag gacaccacca cagugcuugc     4020

caccuuagcu cuccuuggau gugacaucuc gccauggcag ugguuaaaga agaaggcaug     4080

ugauauucug gaaauaccau augucauuaa acagggugau agcugguuga agaaguuuac     4140

ugaggcaugc aacgccgcca aggggcuaga gugggugucu aauaaaauuu caaaguuuau     4200

ugauugguua aaggagaaaa uuauuccaca ggcgagagau aaacuugagu uugucaccaa     4260

acuuaaacaa uuggaaaugc ucgaaaauca gauuuccacg auacaucaau cuugccccag     4320

ccaggaacac caggaaguuc uguucaacaa cgugcggugg uugucaauuc agucuaagaa     4380

guuugcgcca cuuuaugcgc uugaggccaa gagaauacaa aaguuagaac acaccaucaa     4440

uaauuacaua caguucaaga gcaaacaccg uauugaacca guguguuugu uggugcacgg     4500

gagcccaggc accggaaaau caguugcgac caaucuaauu gcuagagcca uagcagagaa     4560

agagaacaca uccaccuacu cacugccacc agacccgucu cacuuugaug guuauaaaca     4620

gcaaggugug gucaucaugg augauuugaa ccaaaaccca gauggggcag auaugaaacu     4680

cuuuugucaa augguaucua cuguggaguu caucccgccu auggccucac uggaagaaaa     4740

aggcauuuug uucacaucca auuaugucuu ggcuuccacc aacuccaguc guaucacacc     4800

acccacagua gcccauagug acgcgcuggc uaggagauuc gccuucgaua uggacauaca     4860

aguaaugggc gaguauucca gagaugguaa acucaacaug gcaauggcca cugagaugug     4920

uaaaaacugc caccaaccag caaacuucaa gagaugcugc ccuuuggugu guggcaaggc     4980

uauucaguug auggacaaau ccucuagagu uagauacagu auugaccaga ucaccacuau     5040

gauuaucaau gagagaaaca gaagauccaa cauagguaau ugcauggagg cucuauucca     5100

aggaccacuc caguacaaag accugaaaau ugacaucaaa acgagucccc ccccugagug     5160

uaucaaugac cugcuacaag caguugacuc ccaagaagug agggauuauu gugaaaagaa     5220

agguuggauu guuaacauua ccagucaagu ucaaacagag agaaacauua aucgggcaau     5280

gacuauuuua caagcaguga caacauucgc ugcaguggcc ggugucgugu acguuaugua     5340

caaacuguuc gcuggccacc agggagcaua cacuggacug ccaaacaaaa gaccuaaugu     5400

acccaccauu agaacagcaa aagugcaagg gccuggauuu gacuacgcug uggcuauggc     5460

caaaagaaac auuguuacag caaccacuag uaagggagag uucaccaugc ugggagugca     5520

cgacaacgug gccauacuac cgacccaugc cucgccuggu gagagcaucg ugaucgaugg     5580

caaggagguu gaaauuuuag acgccaaagc ccucgaagau caagcaggca ccaaucugga     5640

aaucacuaua auaacccuca aaagaaauga gaaguucaga gacaucagau cucacauacc     5700

cacccaaauc acugagacaa augauggagu cuugaucgua aacacuagua aguaccccaa     5760

cauguauguu ccuguuggug cugugaccga acagggauau cucaaucucg gcggacguca     5820

gaccgcgcgu acauugaugu acaacuuucc aacacgagcg ggucaaugcg guggagucau     5880

caccugcacu ggcaaaguca ucgggaugca ugucgguggg aacgguucac auggguucgc     5940

agcagcccua aagcgaucuu acuucacuca gagucaaggu gagauucagu ggaugagacc     6000

aucaaaagag gugggguacc ccaucaucaa ugccccaucu aaaaccaagc uugagcccag     6060

cgccuuucac uauguguuug aagguguuaa agaaccagca guacucacau ggaaugaccc     6120

cagauugaaa acggacuuug aagaagccau cuucuccaag uauguaggga acaagauuac     6180

ugaaguggau gaguacauga aagaagcugu ugaccacuau gcuggucagc ucaugucccu     6240

ggacaucaac acugagcaga ugugccuaga agaugccaug uacggaacug auggauugga     6300

ggccuuggac cuaagcacua gugcaggaua ucccuaugug gcgaugggaa agaagaaaag     6360

agacaucuug aacaaacaga ccagagacac uaaggagaug cagagacugc ucgacaccua     6420

uggaaucaac cuuccguugg ugacguaugu caaagaugag cucagaucaa aagugaaggu     6480

ggaacagggc aagucuagac uaauugaggc auccagcuug aaugauuccg uugccaugag     6540

aauggcauuu gggaaucugu acgcugccuu ucauaagaau ccaggcguug uaacagguuc     6600

cgcaguugga ugugauccag accuauuuug gagcaggauc ccagugcuaa uggaggagaa     6660

gcuuuuugcc uuugauuaca cagguuauga cgccucgcuc aguccugcgu gguuugaggc     6720

acuuaaaaug gugcuugaga aaauuggcuu uggagacaga guagauuaca ucgacuaucu     6780

caaccauucu caccauuugu acaagaacaa aaccuauugu guuaagggug gcaugccauc     6840

uggcugcucu ggcacuucaa uuuucaauuc uaugauuaau aacuuaauua uuaggacacu     6900

auuacugaaa accuacaagg gcauagauuu agaccgccua aagaugaucg ccuaugguga     6960

ugauguaauu gcuuccuacc cccaugaggu ugacgcuagu cuccuagccc aaucaggaaa     7020

agacuaugga cuaaccauga caccagccga uaagucaacg acuuuugaaa cugucacaug     7080

ggagaaugua acauucuuga aaagauucuu cagagcagau gaaaaguacc ccuuucuaau     7140

acacccagua augccaauga aggagauuca cgaaucaauu agauggacaa aagauccaag     7200

gaacacacag gaucauguuc gcucacuaug ccuauuggcg uggcauaaug gcgaagaaga     7260

auauaacaaa uuuuuagcua aaauuagaag ugugccaauc ggaagagcuu uguugcuccc     7320

agaguacucu acacuguacc gccguuggcu ugacucauuu uaguaacccu accucagucg     7380

aauuggauug ggucauacug uugugggggu aaauuuuucu uuaauucgga gaaaaaaaaa     7440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                    7471


<210>  8
<211>  7452
<212>  DNA
<213>  Poliovirus

<400>  8
ttaaaacagc tctggggttg ttcccacccc agaggcccac gtggcggcta gtacactggt       60

atcacggtac ctttgtacgc ctgttttata ctccctcccc cgcaacttag aagcatacaa      120

ttcaagctca ataggagggg gtgcaagcca gcgcctccgt gggcaagcac tactgtttcc      180

ccggtgaggc cgcatagact gttcccacgg ttgaaagtgt ccgatccgtt atccgctcat      240

gtacttcgag aagcctagta tcgctctgga atcttcgacg cgttgcgctc agcactcaac      300

cccggagtgt agcttgggcc gatgagtctg gacagtcccc actggcgaca gtggtccagg      360

ctgcgctggc ggcccacctg tggcccaaag ccacgggacg ctagttgtga acagggtgtg      420

aagagcctat tgagctacat gagagtcctc cggcccctga atgcggctaa ttctaaccat      480

ggagcaggca gctgcaaccc agcagccagc ctgtcgtaac gcgcaagtcc gtggcggaac      540

cgactacttt gggtgtccgt gtttcctttt attcttgaat ggctgcttat ggtgacaatc      600

atagattgtt atcataaagc gagttggatt ggccatccag tgtgaatcag attaattact      660

cccttgtttg ttggatccac tcccgaaacg ttttactcct taacttattg aaattgtttg      720

aagacaggat ttcagtgtca caatgggagc tcaagtatca tcccaaaaag taggcgctca      780

cgagaattct aaccgagcct acggtggttc tacgatcaac tacaccacaa ttaattatta      840

taaagattcc gcaagtaatg cggcgtccaa acaagattac tcacaggatc catcaaaatt      900

caccgagcca ctaaaggacg tgctcataaa aacagctcca gcactcaatt caccaaatgt      960

ggaagcgtgt gggtatagtg atagagtgtt gcaactcact ttaggcaatt ccactattac     1020

tacacaggag gcagcaaatt cagtagtggc ttacggacgt tggcctgagt ttattagaga     1080

tgacgaagca aacccggtgg accaaccaac tgaaccagat gtggctacat gcagattcta     1140

cacactagac actgtaatgt ggggtaagga gtcgaaaggc tggtggtgga agttacctga     1200

cgcactgaga gacatgggtc tgtttggaca aaacatgtat taccactacc taggaagatc     1260

cgggtacact gtgcacgtgc agtgtaatgc atccaaattt caccaaggtg cactcggggt     1320

gtttgcgatt cctgagtatt gtctggcggg tgacagtgac aagcaaaggt acactagtta     1380

tgcaaatgcg aatccaggtg aaagaggggg aaaattttac tcccaattca acaaggataa     1440

cgcagtaaca tccccaaaaa gagagttctg cccagtggat tatctcctgg gatgtggggt     1500

gttactggga aatgcctttg tatacccaca tcaaatcatt aatctgagga ccaacaacag     1560

cgcaactatt gtcctaccat atgtgaatgc tttggccatt gattcaatgg ttaaacacaa     1620

caactggggc attgccattc tgcccttatc accgctggat tttgctcaag attcatcagt     1680

tgaaattcca attactgtga caattgcccc aatgtgtagc gagttcaacg gccttcgcaa     1740

cgtgactgca cctaaatttc aaggactacc agtgttgaac actcctggta gtaaccagta     1800

cctgacgtca gacaaccacc aatcaccatg cgcaatccca gaatttgatg tcactccgcc     1860

tattgatatc ccaggtgagg ttaaaaacat gatggagctc gccgagatag acaccatgat     1920

tcctctcaat ttggagagca ccaagagaaa cacaatggac atgtacagag ttactctgag     1980

cgacagtgcc gatctatcgc aaccaatttt gtgcttgtca ctatccccag catttgatcc     2040

gcgcttgtca cacaccatgc ttggggaagt actgaactat tatactcatt gggccgggtc     2100

cttgaaattt accttcctgt tctgtggttc aatgatggct acggggaaaa tcctagtggc     2160

ctatgcacca ccaggtgcac aaccccccac cagccgtaag gaggctatgt tgggcacaca     2220

tgtcatttgg gatcttggcc tgcaatcatc ttgtactatg gtggtgccgt ggattagtaa     2280

tgtgacatac agacagacta cacaagatag tttcactgag ggcggatata tcagcatgtt     2340

ctaccaaaca agaattgtgg tgccactgtc cacccctaag agtatgagca tgctggggtt     2400

tgtgtcagcc tgtaatgatt tcagtgtgcg attgctgcga gacaccactc acatttcaca     2460

atctgcgctt ccacagggta ttgaagattt gatttctgaa gttgcacagg gcgccctaac     2520

tttgtcactc ccgaagcaac aggatagctt acctgatact aaggccagtg gcccggcgca     2580

ttccaaggag gtacctgcac tcactgcagt cgagactgga gccaccaatc ctctggcacc     2640

atccgacaca gttcaaacgc gccacgtagt ccaacgacgc agcaggtcag agtccacaat     2700

agaatcattc ttcgcacgcg gggcgtgcgt cgctattatt gaggtggaca atgaacaacc     2760

aaccacccgg gcacagaaac tatttgccat gtggcgcatt acatacaaag atacagtgca     2820

gttgcgccgt aagttggagt ttttcacata ctctcgtttt gacatggaat tcaccttcgt     2880

ggtaaccgcc aacttcacca acgctaataa tgggcatgca ctcaaccagg tgtaccagat     2940

aatgtacatc cccccagggg cacccacacc aaagtcatgg gacgactaca cttggcaaac     3000

atcttccaac ccgtccatat tttacaccta tggggctgcc ccggcgcgaa tctcagtgcc     3060

atacgtgggg ttagccaatg cttactcgca cttttacgac ggcttcgcca aggtgccatt     3120

gaagacagat gccaatgacc agattggtga ttccttgtac agcgccatga cagttgatga     3180

ctttggtgta ttggcagttc gtgttgtcaa tgatcacaac cccactaaag taacctccaa     3240

agtccgcatt tacatgaaac ccaaacacgt acgtgtctgg tgccctagac cgccgcgcgc     3300

ggtaccttat tatggaccag gggtggacta taggaacaac ttggacccct tatctgagaa     3360

aggtttgacc acatatggct ttgggcatca gaataaagct gtgtacactg ctggttacaa     3420

gatctgcaac taccatctcg ccactaagga ggatttacaa aatgctgtaa gcatcatgtg     3480

gaatagagac ctcttggttg ttgaatcaaa agctcaaggt accgactcaa tagcaaggtg     3540

caattgcaat gcaggggtgt actattgtga gtccagaagg aaatactacc ctgtgtcgtt     3600

tgtgggaccc accttccaat acatggaggc taatgactac tacccagcta gataccaatc     3660

ccacatgtta atcgggcacg gctttgcctc accaggtgac tgtggtggta tccttaggtg     3720

tcaacatggc gtcatcggaa tcgtgacagc tggtggagag ggattagtcg cattctctga     3780

cataagggac ttgtatgctt acgaggaaga ggccatggag cagggcattt caaactatat     3840

tgagtcactc ggtgctgcgt tcggtagtgg gttcactcag caaatagggg ataagatatc     3900

agaactaacc agcatggtga ccagcacgat tacagagaag ctacttaaaa acctaatcaa     3960

aattatttca tctctggtga ttatcactag aaattacgaa gataccacca cagtgctcgc     4020

cactctagct cttcttgggt gtgatgtttc accgtggcaa tggctgaaga agaaagcatg     4080

tgacactttg gagattccct atgttattag acagggtgat agttggttga aaaaatttac     4140

tgaggcgtgc aacgcagcta aggggttgga atgggtgtcc aacaaaatct caaaatttat     4200

tgactggttg agagaaagaa tcatcccaca agccagggac aagcttgagt ttgtaaccaa     4260

attgaaacag ttggaaatgc tagagaatca gatatccaca atacaccaat cttgtccaag     4320

tcaggaacac caggaaattt tgttcaacaa tgtacgctgg ttgtccattc aatccaagag     4380

attcgctcca ttgtacgcac ttgaggccaa gagaatacaa aagttggaac acaccattaa     4440

taattacata cagttcaaga gcaaacaccg tattgagcca gtatgtttgt tagtgcatgg     4500

gagcccaggt acaggaaaat cagttgcgac taacctaatt gctagagcca tagctgagaa     4560

agagaacacc tccacctact cgctaccacc ggacccgtct cactttgatg gatacaaaca     4620

acaaggtgtg gttatcatgg acgacctaaa ccaaaacccg gatggggcag atatgaagct     4680

cttttgtcaa atggtgtcca ctgtggagtt tatcccacct atggcctcgc tggaagagaa     4740

aggcattctg ttcacatcca actatgtttt agcctccacc aactccagtc gcatcacacc     4800

acctacagta gcccacagtg acgctctggc caggaggttc gctttcgata tggatattca     4860

agtgatgggc gagtactcca gagatggtaa actcaacatg gcaatggcta ctgagacgtg     4920

caaggactgc caccaaccag caaacttcaa aagatgctgt cctttagtgt gtggtaaggc     4980

aattcagtta atggacaaat cttccagagt taggtacagt gttgaccaga ttactacaat     5040

gattatcaac gagagaaaca gaagatctaa cattggcaat tgcatggagg ctttgttcca     5100

aggaccactc cagtacaaag acctgaaaat tgacatcaag acgaggcccc cccctgaatg     5160

catcaatgat ctgcttcaag cagttgactc ccaggaagtg agggattatt gtgaaaagaa     5220

aggatggatc gtcaacatca ctagccaagt tcaaacagag agaaacatta accgagcaat     5280

gaccattttg caggcagtga caactttcgc cgcagtggct ggtgtcgtgt acgtcatgta     5340

caagttattc gctggacacc agggagcata cactggtctg ccaaacaaaa gacccaatgt     5400

gcccaccatt agagcagcaa aagtgcaagg gcctgggttt gactatgcag tggctatggc     5460

taaaagaaac attgttacag caactactag caaaggggag ttcacaatgc taggagtcca     5520

cgacaacgtg gccattttac caactcatgc ctcacctggt gagagtattg taattgatgg     5580

caaagaggtt gaaatcctag acgctaaagc cctcgaagat caggcaggca ctaatctgga     5640

aatcaccata ataaccctca aaagaaatga aaagttcaga gatatcagac aacacatacc     5700

cactcaaatc accgagacga atgatggagt tctgattgtg aacactagta agtaccccaa     5760

catgtatgtt cctgtcggtg ctgtgactga gcagggatac ctaaatctcg gtgggcgcca     5820

gactgctcgt attctaatgt acaactttcc aaccagagct ggtcagtgtg gtggagtcat     5880

cacatgcact gggaaagtca tcgggatgca cgttggtggg aatggttcac atgggtttgc     5940

agcggccctg aagcggtcat acttcactca gagccaaggt gaaatccagt ggatgagacc     6000

atcaaaggag gcagggtatc caattataaa cgccccaacc aagaccaagc tcgagcccag     6060

tgctttccac tatgtgtttg aaggagtaaa ggaaccagca gtcctcacaa agaatgatcc     6120

cagactcaaa acagactttg aagaagcaat cttctctaag tatgtaggga acaagatcac     6180

tgaggtggat gagtacatga aagaggcagt ggaccattat gctggacaac ttatgtcgct     6240

ggatatcagc acagagcaaa tgtgtctaga agacgccatg tatggtactg atggtctgga     6300

ggcgctagat ctgtctacca gtgccgggta cccctacgtg gcaatgggga agaagaagag     6360

agatatccta aacaagcaaa ccagagacac caaagaaatg caaagacttt tggacgctta     6420

cggaatcaac ctaccattag tgacatatgt caaggacgag ctgaggtcca aaacaaaagt     6480

ggaacaggga aaatccagac tgattgaagc ttccagtcta aatgactcag tggccatgag     6540

aatggcattt ggaaaccttt atgcagcatt ccacaggaat ccaggggtcg tcactggtag     6600

tgcagttgga tgcgatccag acctattctg gagcaagatc ccagtgttga tggaagaaaa     6660

gctatttgcc tttgattaca caggatacga cgcatcactt agcccagctt ggtttgaggc     6720

actcaagatg gtgttagaga aaattggttt tggagataga gtggattaca tagactacct     6780

taaccattca caccacttgt acaaaaacaa gatatattgt gttaagggcg gcatgccatc     6840

tggctgctcc ggcacttcaa tttttaattc aatgattaac aatttgatca ttaggacgct     6900

tttactgaaa acctacaagg gcatagattt ggaccactta aaaatgattg cctatggtga     6960

cgatgtaata gcttcctatc cccatgaggt tgacgctagt ctcctagccc aatcaggaaa     7020

agactatgga ctaaccatga ctccggcaga taaatctgcc acttttgaga cagtcacatg     7080

ggagaatgta actttcttga aaagattctt cagagcagat gagaaatacc ccttcctcat     7140

acatccagta atgccaatga aggaaattca tgaatcaatc agatggacaa aagatcctcg     7200

gaatacgcag gaccatgtac gctccttgtg tctattggct tggcacaacg gggaagaaga     7260

atacaacaaa tttttagcta aaattaggag tgtgccaatc ggaagagctt tgttgctccc     7320

agagtactca acattgtacc gccgttggct tgactcattt tagtaaccct acctcagtcg     7380

aattggattg ggtcatactg ttgtaggggt aaatttttct ttaattcgga ggaaaaaaaa     7440

aaaaaaaaaa aa                                                         7452


<210>  9
<211>  7462
<212>  DNA
<213>  Poliovirus

<400>  9
ttaaaacagc tctggggttg cacccacccc agaggcccac gtggcggcta gtactccggt       60

attgcggtac ccttgtacgc ctgttttata ctcccttccc gtaacttaga cgcacaaaac      120

caagttcaat agaagggggt acaaaccagt accaccacga acaagcactt ctgtttcccc      180

ggtgatgttg tatagactgc ttgcgtggtt gaaagcgacg gatccgttat ccgcttatgt      240

acttcgagaa gcccagtacc acctcggaat cttcgatgcg ttgcgctcag cactcaaccc      300

cagagtgtag cttaggctga tgagtctgga catccctcac cggtgacggt ggtccaggct      360

gcgttggcgg cctacctatg gctaacgcca tgggacgcta gttgtgaaca aggtgtgaag      420

agcctattga gctacataag aatcctccgg cccctgaatg cggctaatcc caacctcggg      480

gcaggtggtc acaaaccagt gattggcctg tcgtaacgcg caagtccgtg gcggaaccga      540

ctactttggg tgtccgtgtt tccttttatt ttattgtggc tgcttatggt gacaatcaca      600

gattgttatc ataaagcgaa ttggattggc catccggtga aagtgagatt cattatctat      660

ctgtttgctg gattcgctcc attgagtgtg tttactctaa gtacaatttc aacagttatt      720

tcaatcagac aattgtatca taatgggtgc tcaggtttca tcacagaaag tgggcgcaca      780

tgaaaactca aatagagcgt atggtggttc taccattaat tacaccacca ttaattatta      840

tagagattca gctagtaacg cggcttcgaa acaggacttc tctcaagacc cttccaagtt      900

caccgagccc atcaaggatg tcctgataaa aacatcccca atgctaaact cgccaaacat      960

agaggcttgc gggtatagcg atagagtact gcaattaaca ctgggaaact ccactataac     1020

cacacaggag gcggctaatt cagtagtcgc ttatgggcgt tggcctgaat atctgaggga     1080

cagcgaagcc aatccagtgg accagccgac agaaccagac gtcgctgcat gcaggtttta     1140

tacgctagac accgtgtctt ggacgaaaga gtcgcgaggg tggtggtgga agttgcctga     1200

tgcactgcgg gacatgggac tctttggcca aaatatgtac taccactacc taggtaggtc     1260

cgggtacacc gtgcatgtac agtgtaacgc ctccaaattc caccaggggg cactaggggt     1320

attcgccgta ccagagatgt gtctggccgg ggatagcaac accactacca tgcacaccag     1380

ctatcaaaat gccaatcctg gcgagaaagg aggcactttc acgggtacgt tcactcctga     1440

cgacaaccag acatcacctg cccgtaggtt ctgcccggtg gattacctct ttggaaatgg     1500

cacgttattg gggaatgcct ttgtgttccc gcaccagata ataaacctac ggaccaacaa     1560

ctgtgctaca ctggtactcc cttacgtgaa ctccctctcg atagatagta tggtaaagca     1620

caataattgg ggaattgcaa tattaccatt ggccccatta aattttgcta gtgagtcctc     1680

cccagagatt ccaatcacct tgaccatagc ccctatgtgc tgtgagttca atggattaag     1740

aaacattacc ctgccacgct tacagggcct gccggtcatg aacacccctg gtagcaatca     1800

atatcttact gcagacaact tccagtcacc gtgtgcgctg cctgaatttg atgtgacccc     1860

acctattgac atacccggtg aagttaagaa catgatggaa ttggcagaaa tcgacaccat     1920

gattcccttt gacttaagtg caaaaaaaaa gaacaccatg gaaatgtata gggttcggtt     1980

aagtgacaaa ccacatacag acgatcccat actctgcctg tcactctctc cagcttcaga     2040

tcctaggttg tcacatacta tgcttggaga aatcctaaat tactacacac actgggcagg     2100

atccctgaag ttcacgtttc tgttctgtgg atccatgatg gcaactggca aactgttggt     2160

gtcatacgcg cctcctggag ccgacccacc aaagaagcgt aaggaggcga tgttgggaac     2220

acatgtgatc tgggacatag gactgcagtc ctcatgtact atggtagtgc catggattag     2280

caacaccacg tatcggcaaa ccatagatga tagtttcacc gaaggcggat acatcagcgt     2340

cttctaccaa accagaatag tcgtccctct ttcgacaccc agagagatgg acatccttgg     2400

ttttgtgtca gcgtgtaatg acttcagcgt gcgcttgatg cgagatacca cacatataga     2460

gcaaaaagcg ctagcacagg ggttaggtca gatgcttgaa agcatgattg acaacacagt     2520

ccgtgaaacg gtgggggcgg caacgtctag agacgctctc ccaaacactg aagccagtgg     2580

accagcacac tccaaggaaa ttccggcact caccgcagtg gaaactgggg ccacaaatcc     2640

actagtccct tctgatacag tgcaaaccag acatgttgta caacataggt caaggtcaga     2700

gtctagcata gagtctttct tcgcgcgggg tgcatgcgtg gccattataa ccgtggataa     2760

ctcagcttcc accaagaata aggataagct atttacagtg tggaagatca cttataaaga     2820

tactgtccag ttacggagga aattggagtt cttcacctat tctagatttg atatggaatt     2880

tacctttgtg gttactgcaa atttcactga gactaacaat gggcatgcct taaatcaagt     2940

gtaccaaatt atgtacgtac caccaggcgc tccagtgccc gagaaatggg acgactacac     3000

atggcaaacc tcatcaaatc catcaatctt ttacacctac ggaacagctc cagcccggat     3060

ctcggtaccg tatgttggta tttcgaacgc ctattcacac ttttacgacg gtttttccaa     3120

agtaccactg aaggaccagt cggcagcact aggtgactcc ctctatggtg cagcatctct     3180

aaatgacttc ggtattttgg ctgttagagt agtcaatgat cacaacccga ccaaggtcac     3240

ctccaaaatc agagtgtatc taaaacccaa acacatcaga gtctggtgcc cgcgtccacc     3300

gagggcagtg gcgtactacg gccctggagt ggattacaag gatggtacgc ttacacccct     3360

ctccaccaag gatctgacca catatggatt cggacaccaa aacaaagcgg tgtacactgc     3420

aggttacaaa atttgcaact accatttggc cactcaggaa gatttgcaaa acgcagtgaa     3480

cgtcatgtgg aatagagacc tcttagtcac agaatcaaga gcccagggca ccgattcaat     3540

cgcaaggtgc aattgcaacg caggggtgta ctactgcgag tctagaagga aatactaccc     3600

agtatccttc gttggcccaa cgttccagta catggaggct aataactatt acccagctag     3660

gtaccagtcc catatgctca ttggccatgg attcgcatct ccaggggatt gtggtggcat     3720

actcagatgt caccacgggg tgatagggat cattactgct ggtggagaag ggttggttgc     3780

atttacagac attagagact tgtatgccta cgaagaagaa gccatggaac aaggcatcac     3840

caattacata gagtcacttg gggccgcatt tggaagtgga tttactcagc agattggaga     3900

caaaataaca gagttgacta atatggtgac cagtaccatc actgaaaagc tacttaagaa     3960

cttgatcaag atcatatcct cactagttat tataactagg aattatgaag acaccacaac     4020

agtgctcgct accctggccc ttcttgggtg tgatgcttca ccatggcagt ggcttagaaa     4080

gaaagcatgc gatgttctgg agatacctta tgtcaccaag caaggtgaca gttggttgaa     4140

gaagtttact gaagcatgca acgcagctaa gggactggag tgggtgtcaa acaaaatctc     4200

aaaattcatt gattggctca aggagaaaat tatcccacaa gctagagata agttggaatt     4260

tgtaacaaaa cttagacaac tagaaatgct ggaaaaccaa atctcaacta tacaccaatc     4320

atgccctagt caggaacacc aggaaattct attcaataat gtcagatggt tatccatcca     4380

gtctaagagg tttgcccctc tttacgcagt ggaagccaaa agaatacaga aactagagca     4440

taccattaac aactacatac agttcaagag caaacaccgt attgaaccag tatgtttgct     4500

agtacatggc agccccggaa caggtaaatc tgtagcaacc aacctgattg ctagagccat     4560

agctgaaaga gaaaacacgt ccacgtactc gctacccccg gatccatcac acttcgacgg     4620

atacaaacaa cagggagtgg tgattatgga cgacctgaat caaaacccag atggtgcgga     4680

catgaagctg ttctgtcaga tggtatcaac agtggagttt ataccaccca tggcatccct     4740

ggaggagaaa ggaatcctgt ttacttcaaa ttacgttcta gcatccacga actcaagcag     4800

aatttccccc cccactgtgg cacacagtga tgcattagcc aggcgctttg cgttcgacat     4860

ggacattcag gtcatgaatg agtattctag agatgggaaa ttgaacatgg ccatggctac     4920

tgaaatgtgt aagaactgtc accaaccagc aaactttaag agatgctgtc ctttagtgtg     4980

tggtaaggca attcaattaa tggacaaatc ttccagagtt agatacagta ttgaccagat     5040

cactacaatg attatcaatg agagaaacag aagatccaac attggcaatt gtatggaggc     5100

tttgttccaa ggaccactcc agtataaaga cttgaagatt gacatcaaga cgagtccccc     5160

tcctgaatgt atcaatgact tgctccaagc agttgactcc caggaggtga gagattactg     5220

tgagaagaag ggttggatag tcaacatcac cagccaggtt caaacagaaa ggaacatcaa     5280

cagggcaatg acaattctac aagcggtgac aaccttcgcc gcagtggctg gagttgtcta     5340

tgtcatgtat aaactgtttg ctggacacca gggagcatac actggtttac caaacaaaaa     5400

acccaacgtg cccaccatta ggacagcaaa ggtacaaggg ccagggttcg attacgcagt     5460

ggctatggct aaaagaaaca ttgttacagc aactactagc aagggagagt tcactatgtt     5520

aggagtccac gacaacgtgg ctattttacc aacccacgct tcacctggtg aaagcattgt     5580

gatcgatggc aaagaagtgg agatcttgga tgccaaagcg ctcgaagatc aagcaggaac     5640

caatcttgaa atcactataa tcactctaaa gagaaatgaa aagttcagag acattagacc     5700

acatatacct actcaaatca ctgagacaaa tgatggagtc ttgatcgtga acactagcaa     5760

gtaccccaat atgtatgttc ctgtcggtgc tgtgactgaa cagggatatc taaatctcgg     5820

tgggcgccaa actgctcgta ctctaatgta caactttcca accagagcag gacagtgtgg     5880

tggagtcatc acatgtactg ggaaagtcat cgggatgcat gttggtggga acggttcaca     5940

cgggtttgca gcggccctga agcgatcata cttcactcag agtcaaggtg aaatccagtg     6000

gatgagacct tcgaaggaag tgggatatcc aatcataaat gccccgtcca aaaccaagct     6060

tgaacccagt gctttccact atgtgtttga aggggtgaag gaaccagcag tcctcactaa     6120

aaacgatccc aggcttaaga caaactttga ggaggcaatt ttctccaagt acgtgggtaa     6180

caaaattact gaagtggatg agcacatgaa agaggcagta gaccactatg ctggccagct     6240

catgtcacta gacatcaaca cagaacaaat gtgcttggag gatgccatgt atggcactga     6300

tggtctagaa gcacttgatt tgtccaccag tgctggctac ccttatgtag caatgggaaa     6360

gaagaagaga gatatcttga acaaacaaac cagagacact aaggaaatgc aaaaactgct     6420

cgacacatat ggaatcaacc tcccactggt gacttatgta aaggatgaac ttagatccaa     6480

aacaaaggtt gagcagggga aatccagatt aattgaagct tctagtttga atgactcagt     6540

ggcaatgaga atggcttttg ggaacctata tgctgctttt cacaaaaacc caggagtgat     6600

aacaggttca gcagtagggt gcgatccaga tttgttttgg agcaaaattc cggtattgat     6660

ggaagagaag ctgtttgcct ttgactacac agggtatgat gcatctctca gccctgcttg     6720

gttcgaggca ctaaagatgg tgcttgagaa aatcggattc ggagacagag ttgactacat     6780

cgactaccta aaccactcac accacctgta caagaataaa acatactgtg tcaagggcgg     6840

tatgccatct ggttgctcag gcacttcaat ttttaactca atgattaaca acttgattat     6900

caggacactc ttactgaaaa cctacaaggg catagattta gaccacctaa aaatgattgc     6960

ctatggtgat gatgtaattg cttcctaccc ccatgaagtt gacgctagtc tcctagccca     7020

atcaggaaaa gactatggac taactatgac tccagctgac aaatcagcta tatttgaaac     7080

agtcacatgg gagaatgtaa cattcttgaa gagattcttc agggcagacg agaaataccc     7140

atttcttatt catccagtaa tgccaatgaa ggaaattcat gaatcaatta gatggacaaa     7200

agatcctagg aacactcagg atcacgttcg ctctctgtgc ctattagctt ggcacaatgg     7260

cgaagaagaa tataacaaat tcctagctaa aatcaggagt gtgccaattg gaagagcttt     7320

attgctccca gagtactcaa cattgtaccg ccgttggctt gactcatttt agtaacccta     7380

cctcagtcga attggattgg gtcatactgc tgtaggggta aatttttctt taattcggag     7440

gaaaaaaaaa aaaaaaaaaa aa                                              7462


<210>  10
<211>  7468
<212>  DNA
<213>  Poliovirus

<400>  10
ttaaaacagc tctggggttg tacccacccc agaggcccac gtggcggcta gcactccggt       60

attacggtac ccttgtgcgc ctgttttata ctcccctccc gcaacttaga agcacgaaac      120

caagttcaat agaagggggt acaaaccagt accactacga acaagcactt ctgtttcccc      180

ggtgacattg catagactgc tcacgcggtt gaaagtgatc gatccgttac ccgcttgtgt      240

acttcgaaaa gcctagtatc gccttggaat cttcgacgcg ttgcgctcag cacccgaccc      300

cggggtgtag cttaggctga tgagtctgga cattcctcac cggtgacggt ggtccaggct      360

gcgttggcgg cctacctatg gctaacgcca taggacgtta gatgtgaaca aggtgtgaag      420

agcctattga gctacataag agtcctccgg cccctgaatg cggctaatcc taaccacgga      480

acaggcggtc gcgaaccagt gactggcttg tcgtaacgcg caagtctgtg gcggaaccga      540

ctactttggg tgtccgtgtt tcctgttatt tttatcatgg ctgcttatgg tgacaatcag      600

agattgttat cataaagcga attggattgg ccatccggtg agtgttgtgt caggtataca      660

actgtttgtt ggaaccactg tgttagcttt acttctcatt taaccaatta atcaaaaaca      720

atacgaggat aaaacaacaa tactacaatg ggcgcccaag tttcatcaca gaaagttgga      780

gcccacgaaa attcaaacag agcctatggc gggtccacca tcaattacac tacaatcaat      840

tactataggg actctgcaag caatgcagca agcaagcaag attttgcaca agatccgtcc      900

aagttcaccg aacccattaa ggacgtcctt attaagaccg ctcccatgct aaactcccca      960

aacattgagg cgtgtggtta tagtgacagg gtaatgcagc taactctggg caattcaacg     1020

atcaccaccc aagaagcggc caattctgtt gttgcctacg gtagatggcc tgaatacatc     1080

agagataccg aggcaaatcc tgtagaccaa ccaaccgagc ccgatgtagc cgcgtgcagg     1140

ttctacacat tagataccgt cacttggcgc aaggagtcca gagggtggtg gtggaaacta     1200

ccagacgctt taaaagacat ggggttattt ggtcaaaaca tgttttatca ctatcttggg     1260

agggctggct acacagtgca cgtacagtgc aatgcttcaa agtttcatca aggagctcta     1320

ggggtgtttg cagttccaga aatgtgttta gctggtgata gcacaactca catgttcaca     1380

aagtacgaga atgcgaatcc aggcgaaaaa ggaggtgaat tcaaagggag tttcaccctt     1440

gataccaacg ccactaaccc tgcacggaac ttctgcccag ttgattacct cttcgggagt     1500

ggagtgctgg tagggaatgc atttgtttat ccacatcaaa taataaacct gcgcactaac     1560

aactgtgcta cgctagtatt gccctatgta aactcactct caatagatag catgacaaag     1620

cacaacaact gggggatcgc tatcctcccc ctggcgccac tagactttgc cactgaatct     1680

tccactgaga tacccattac actgaccatt gctcccatgt gctgcgaatt caatggttta     1740

cgcaacatca ctgtgccaag aacccaagga ttaccagtcc tgaacactcc agggagtaac     1800

cagtacctga ccgcagacaa ttaccagtct ccgtgtgcga tacctgagtt tgatgtcact     1860

ccacccatag acataccagg ggaggtgcgc aacatgatgg aattggcgga aatagacacc     1920

atgatacccc tcaacttgac aagtcaacgc aagaacacaa tggacatgta tagagtcgag     1980

ttgagcgaca cggctcactc tgacacgccg atcttgtgtc tctcgttgtc ccccgcttca     2040

gaccccagat tggcacacac tatgttgggt gagatattaa attactacac acactgggca     2100

gggtccttga aatttacctt tctcttttgc ggctcaatga tggccaccgg aaagttattg     2160

gtttcttacg caccacccgg agcagaggcc cccaagagtc gcaaagaagc aatgcttggg     2220

acacatgtga tatgggacat tgggttgcag tcttcatgca ctatggtggt accttggatc     2280

agtaatacca catacagaca aaccatcaac gatagtttca cagaaggtgg ctacattagc     2340

atgttctatc aaactagggt tgttgtcccg ttgtccacac ccagaaagat ggacatcctg     2400

ggttttgtgt cagcttgcaa tgacttcagt gtgcgcttac tgcgagatac aacacacatt     2460

agtcaagagg ctatgccaca aggaattggt gacatgattg agggggccgt tgaagggatt     2520

actaaaaatg cattggttcc cccgacttcc accaatagcc tgcctgacac aaagccgagc     2580

ggtccagccc actccaagga gatacctgca ttgacagccg tggagacagg ggctaccaat     2640

ccgttggtgc cttcggacac cgtgcaaacg cgccatgtca tccagagacg aacgcgatca     2700

gagtccacgg ttgagtcatt ctttgcaaga ggggcttgcg tggctatcat tgaggtggac     2760

aatgatgcac cgacaaagcg cgccagcaga ttgttttcgg tttggaaaat aacttacaaa     2820

gatactgttc aactgagacg caaactggaa tttttcacat attcgagatt tgacatggag     2880

ttcacttttg tggtcacctc aaactacatt gatgcaaata acggacatgc attgaaccaa     2940

gtttatcaga taatgtatat accacccgga gcacctatcc ctggtaaatg gaatgactat     3000

acgtggcaga cgtcctctaa cccgtcggtg ttttacacct atggggcgcc cccagcaaga     3060

atatcagtgc cctacgtggg aattgctaat gcgtattccc acttttatga tgggtttgca     3120

aaagtaccac tagcgggtca agcctcaact gaaggcgatt cgttgtacgg tgctgcctca     3180

ctgaatgatt ttggatcact ggctgttcgc gtggtaaatg atcacaaccc cacgcggctc     3240

acctccaaga tcagagtgta catgaagcca aagcatgtca gagtctggtg cccacgacct     3300

ccacgagcag tcccatactt cggaccaggt gttgattata aagatgggct caccccacta     3360

ccagaaaagg gattaacgac ttatggattt ggacaccaaa acaaagctgt gtacacagct     3420

ggctacaaaa tttgcaatta ccacctagct acacaagaag acttgcaaaa tgccgtgagt     3480

gtcatgtgga acagagacct cttagtggct gaatcaaggg cccttggcac cgactcgatc     3540

gcaaggtgca gctgtaacac gggtgtgtac tactgtgaat ccaggagaaa atattatcca     3600

gtttctttca ttgggcccac cttccaatac atggaagcca atgaatatta cccggctaga     3660

tatcaatcac acatgcttat tggtcatggg tttgcatcac cgggtgattg tggtggcata     3720

cttagatgtc aacacggggt gataggaata atcactgctg gtggggaagg cttggttgca     3780

ttttcagaca ttagagacct gtatgcttat gaggaggaag ctatggagca gggcatttcc     3840

aactatattg agtcacttgg tgctgcattt ggtagtggat tcactcaaca aattggtgat     3900

aaagtttccg agctaaccag catggtaact agcaccatta cagagaagtt gcttaaaaac     3960

ttaatcaaaa ttatctcatc acttgtgatc attaccagga attatgagga cactaccaca     4020

gtgcttgcca ccctcgccct ccttgggtgc gacatctcac cgtggcagtg gctaaagaag     4080

aaggcatgtg acatcctgga aattccatac gccatcaaac aaggagatag ttggttgaag     4140

aaattcactg aggcatgtaa tgctgcaaag ggactggagt gggtgtccaa taagatatcc     4200

aaattcatta gttggttgca ggataaaatc atcccacaag cgagagacaa attagagttt     4260

gtcactaaac taaagcaatt agaaatgctt gaaaatcaga tttccaccat acaccaatct     4320

tgtccaagtc aagaacatca ggagatctta ttcaacaatg tgcggtggct atctatccag     4380

tccaagaggt ttgcaccact atatgcacat gaagctaaaa ggattcaaaa gctggagcat     4440

accataaata attacgtaca gttcaagagc aagcaccgta ttgagccagt atgtttgtta     4500

gtacatggca gtccagggac aggaaaatca gttgcaacca atctaattgc tagagcaata     4560

gccgagaaag agaacacctc cacatactca ctgccacctg atccgtctca ctttgatggc     4620

tacaagcaac agggtgtggt tattatggat gacctaaacc aaaatccaga cggagcagac     4680

atgaaacttt tttgtcaaat ggtgtccact gtggagttta ttccaccgat ggcctcgcta     4740

gaagagaaag gcattttgtt cacatctaat tacgttttag cctccaccaa ctccagtcgg     4800

atcacaccac ccacggtggc tcacagtgat gcgctggcca ggagattcgc atttgacgtg     4860

gacatacaag tcatgagcga gtactccaga gacggaaagc tcaacatggc aatggctact     4920

gaaatgtgca aaaactgtca tcaaccagca aacttcaaaa gatgttgtcc tttagtgtgt     4980

ggcaaggcaa ttcagttaat ggataaatct tccagggtta gatacagcat tgatcagatc     5040

actacaatga ttgttaatga gagaaacaga agatcaaaca ttggtaattg catggaagct     5100

ctattccagg gaccactgca gtataaagat ctaaaaatag atgttaagac cagtccccct     5160

ccggagtgta tcaacgattt gctccaggca gttgattccc aggaagtgag agattactgt     5220

gaaaagaaag gctggattgt taacattacc agtcaggttc aaacagagag gaacatcaac     5280

cgggcgatga ctatcctaca agcagtaact actttcgctg cagtagccgg tgtcgtgtac     5340

gttatgtaca agctgttcgc tgggcaccag ggtgcataca ctggtttgcc aaataaacga     5400

cccaatgtac ccactatcag gacagcaaaa gtgcaaggcc ctgggtttga ttacgcagtg     5460

gccatggcta aaagaaacat tgttacagca accaccagca aaggggagtt tacgatgttg     5520

ggagtctatg ataatgtggc catcttgcca acccacgcct cacctggtga aagcattgcg     5580

atcgacggta aagaggtgga aattcttgac gccaaagccc ttgaagatca ggcaggaact     5640

aatcttgaaa ttaccataat tacactaaag aggaacgaga agttcagaga tatcaggcca     5700

cacattccca cccaaatcac cgaaacaaat gatggagttt tgatcgtgaa cactagtaag     5760

taccccaaca tgtatgttcc cgttggtgct gtgaccgaac aggggtatct taatctcggt     5820

ggacgacaaa ccgctcgtac gctaatgtac aactttccaa ctagagcagg tcagtgtggt     5880

ggtgtcatca cgtgcactgg taaagtcatt gggatgcatg ttggtgggaa cggttcacat     5940

gggttcgcgg cggccctaaa gcggtcatac ttcactcaga ttcaaggtga gattcaatgg     6000

atgaaaccat caaaagaagt gggatacccg atcataaatg ctccgtccaa aaccaaactt     6060

gaacccagcg cttttcacta tgtgtttgaa ggggtgaagg aaccagcagt ccttaccaaa     6120

aatgatccca ggctcaggac agactttgaa gaagcaatat tctctaagta tgtaggcaac     6180

aagatcactg atgtggatga gtacatgaaa gaggcagtgg atcattacgc tggccaactc     6240

atgtctctag acatcaacac agaacaaatg tgcttggagg acgccatgta cggcaccgat     6300

ggcctggaag cacttgactt gaccactagt gctggatacc cttatgtagc aatgggaaag     6360

aaaaagagag acatcttgaa taagcagact agagacacca aggaaatgcg gagactctta     6420

gatacttatg gaattaactt accgcttgta acatatgtta aagatgaact aaggtcaaaa     6480

actaaggtgg agcagggaaa atccagattg attgaagcct ccagtttgaa tgattcagtg     6540

gccatgagaa tggcatttgg aaatctctat gcagcatttc acaaaaaccc aggagttgtc     6600

actggcagtg cagttggttg tgatccagat ctattttgga gcaagatccc agtgctaatg     6660

gaagagaagc tctttgcttt tgactacaca ggttatgatg catcactcag cccggcctgg     6720

tttgaggcac tcaaaatggt gctagagaaa atcggatttg gggacagggt ggattatatt     6780

gattacctca accattccca ccacctgtac aaaaacaaaa cttattgcgt aaaaggcggc     6840

atgccatctg gctgctcagg cacatcaatt tttaactcaa tgattaacaa cttaatcatt     6900

aggacactcc tactgaaaac ctacaagggc atagatttag atcacctaaa gatgattgcc     6960

tatggtgatg atgtaattgc ttcctacccc catgaggttg atgctagtct cctagcccaa     7020

tcaggaaaag actatggact aaccatgact ccagcagaca agtcagctac ctttgaaaca     7080

gtcacatggg agaatgtaac attcttgaaa agattcttta gagcggatga gaagtatccc     7140

ttcctcatac atccagtaat gccaatgaag gagattcatg aatcaattag atggacaaag     7200

gatcccagaa acacacagga tcacgtgcgc tcattgtgcc tattggcctg gcacaacggc     7260

gaagaagaat acaacaagtt cttagctaaa atcaggagtg tgccaattgg gagagcttta     7320

ttgctcccag agtactctac attgtaccgc cgttggctcg actcttttta gtaaccctac     7380

ctcagtcgaa ttggattggg tcatgctgtt gtaggggtaa atttttcttt aattcgggga     7440

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                        7468


